ArticleThe British journal of dermatology2014
Prospective study of infantile haemangiomas: incidence, clinical characteristics and association with placental anomalies.
Article in The British journal of dermatology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 122 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
122 citing papers in PubMed, 2 syntheses or guidelines pooled it, 310 citations in OpenAlex.
- Efficacy and safety of interventions for infantile hemangioma compared with oral propranolol: an updated systematic review and bayesian network meta-analysis.European journal of pediatrics · 2026Pooled it
- Efficacy and adverse effects of oral propranolol in infantile hemangioma: a meta-analysis of comparative studies.World journal of pediatrics : WJP · 2019Pooled it
- To compare intralesional and oral propranolol for treating periorbital and eyelid capillary hemangiomas.Indian journal of ophthalmology · 2019Trial
- Trial
- Comparison of Efficacy and Safety Between Propranolol and Steroid for Infantile Hemangioma: A Randomized Clinical Trial.JAMA dermatology · 2017Trial
- Ulcerated infantile hemangioma in the β-blocker era: recent advances.World journal of pediatrics : WJP · 2026Review
- Review
- Life-Threatening Complications and Intensive Care of Diffuse Neonatal Hemangiomatosis of the Liver in a One-Month-Old Girl: A Case Report.Children (Basel, Switzerland) · 2026Article
- The Importance of Continuous Monitoring in Identifying Bradycardia during Propranolol Treatment for Infantile Hemangiomas.JMA journal · 2026Article
- Pulsed ultrasound-stimulated microbubbles alter the tumor blood supply to enhance the efficacy of high-intensity focused ultrasound ablation of vascular tumors.Frontiers in oncology · 2026Article
- Key cellular subpopulations and mechanisms of propranolol in infantile hemangioma: insights from single-cell omics.Frontiers in medicine · 2026Review
- Complications of Topical Timolol in the Management of Infantile Hemangiomas: A Systematic Review.The Journal of clinical and aesthetic dermatology · 2025Review
- Unveiling Infantile Hemangiomas: A Comprehensive Study of Patterns, Presentations, and Complications.Dermatology practical & conceptual · 2025Article
- Timing of treatment with oral propranolol for infantile hemangioma.BMC pediatrics · 2025Article
- The Regression Heterogeneity Pattern of Infantile Haemangiomas after Treatment with Propranolol: A Multicentre Retrospective Study.Acta dermato-venereologica · 2025Article
- PHACE syndrome: looking backward and forward.Orphanet journal of rare diseases · 2025Review
- Knowledge, attitudes, and practices on hemangioma among parents of infantile hemangioma patients in South China.Scientific reports · 2025Article
- Research trends and hotspots of laser therapy in hemangioma: a bibliometric and visualization analysis.Lasers in medical science · 2025Review
- Mesenchymal Tumors of the Liver: An Update Review.Biomedicines · 2025Review
- Nanotechnology in Infantile Hemangioma Management.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG · 2025Article
62 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 6 institutions in 1 country.
Funding
Abstract
backgroundThe aetiology and exact incidence of infantile haemangiomas (IHs) are unknown. Prior studies have noted immunohistochemical and biological characteristics shared by IHs and placental tissue.
objectivesWe investigated the possible association between placental anomalies and the development of IHs, as well as the demographic characteristics and other risk factors for IHs. PATIENTS AND
methodsPregnant women (n = 578) were prospectively enrolled and their offspring followed for 9 months. Placental evaluations were performed and demographic data collected on all mother-infant pairs.
resultsWe evaluated 594 infants: 34 haemangiomas [either IH or congenital (CH)] were identified in 29 infants, yielding an incidence of 4·5% for IH (27 infants) and 0·3% for CH (two infants). Placental anomalies were noted in almost 35% of haemangioma-related pregnancies, approximately twice the incidence noted in pregnancies with unaffected infants (P = 0·025). Other risk factors for IH included prematurity (P = 0·016) and low birth weight (P = 0·028). All IHs were present by 3 months of age, and cessation of growth had occurred in all by 9 months of age. Most occurred on the trunk. Of note, 20% of identified IHs were abortive or telangiectatic in nature, small focal lesions that did not proliferate beyond 3 months of age. Only one IH required intervention.
conclusionsThis is the first prospective American study to document the incidence of IHs in infants followed from birth to early infancy. The association with placental anomalies was statistically significant. The overall incidence mirrors prior estimates, but the need for treatment was lower than previously reported.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.