ArticleGerms2014
Disseminated tuberculosis in HIV-infected patients from the Regional HIV/AIDS Center Constanţa, Romania.
Article in Germs, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 12 citations in OpenAlex.
- Article
- Primary adrenocortical insufficiency in patients with AIDS in Wuhan, China: 3 cases report and literature review.BMC infectious diseases · 2025Review
- Host Immunity to Mycobacterium tuberculosis Infection Is Similar in Simian Immunodeficiency Virus (SIV)-Infected, Antiretroviral Therapy-Treated and SIV-Naïve Juvenile Macaques.Infection and immunity · 2023Article
- Fungal esophagitis associated with tuberculous pericarditis in an human immunodeficiency virus-positive patient: a case report.Journal of medical case reports · 2022Article
- Disseminated Tuberculosis: A 3-Year Case-Series Experience in a Tertiary Care Center.Turkish thoracic journal · 2021Article
- Delays to anti-tuberculosis treatment intiation among cases on directly observed treatment short course in districts of southwestern Ethiopia: a cross sectional study.BMC infectious diseases · 2019Article
- Effect of Empiric Anti-Open forum infectious diseases · 2019Article
- Adrenal Insufficiency: A Forgotten Diagnosis in HIV/AIDS Patients in Developing Countries.International journal of endocrinology · 2019Review
- Map the gap: missing children with drug-resistant tuberculosis.Public health action · 2015Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThe purpose of our study was to evaluate clinical and pathological characteristics as well as treatment outcomes in HIV-infected patients with disseminated tuberculosis from the Regional HIV/AIDS Center Constanţa, Romania, and to determine associated risk factors.
methodsWe analyzed HIV-infected adults diagnosed with disseminated tuberculosis (TB) over the past two years, monitored in the Regional HIV/AIDS Center Constanţa.
resultsOut of a total number of 956 HIV-infected patients, 42 had been diagnosed with tuberculosis over the past two years (2011-2013) (4.39%) and 16 of them developed disseminated TB (38%). At the time of diagnosis, we recorded abnormal chest X-rays in 8 (50%), and positive sputum cultures in 4 (25%) of them. The median CD4 count was 40 cells/μL with a range of 5-85 cells/μL; HIV-RNA was detectable in all cases. Multidrug-resistant tuberculosis (MDR-TB) was identified in 6 cases. The outcome was unfavorable in 15 patients.
conclusionIn our study, disseminated tuberculosis appeared to be a common pattern of evolution of HIV-TB co-infection (38%). Sputum smear positivity was low and chest X-ray images did not follow a typical pattern. HIV-TB co-infected patients with CD4 lymphocyte cell count <50 cells/μL were more likely to have disseminated TB. The severity of cases, proved by a high mortality rate, requires consideration of this diagnosis early in patients with advanced AIDS, even if laboratory investigations are not suggestive.
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