ReviewFrontiers in cellular and infection microbiology2014
Specific sulfation and glycosylation-a structural combination for the anticoagulation of marine carbohydrates.
Review in Frontiers in cellular and infection microbiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 47 citations in OpenAlex.
- Bioactive Glycosaminoglycans fromMarine drugs · 2026Article
- Binding properties of marine sulfated glycans to coagulation (co)-factors using surface plasmon resonance spectroscopy.Scientific reports · 2026Article
- Identification of the D-glucuronyl C5-epimerase that introduces iduronic acid into N-linked glycans decorating archaeal glycoproteins.Communications biology · 2025Article
- Heparan-6-O-endosulfatase 2, a cancer-related proteoglycan enzyme, is effectively inhibited by a specific sea cucumber fucosylated glycosaminoglycan.Glycobiology · 2025Article
- Expanding the Role of Heparin Derivatives in Oncology: From Anticoagulation to Antitumor Activity.Pharmaceuticals (Basel, Switzerland) · 2025Review
- Structure and Binding Properties to Blood Co-Factors of the Least Sulfated Galactan Found in the Cell Wall of the Red AlgaMarine drugs · 2024Article
- Direct antitumoral effects of sulfated fucans isolated from echinoderms: a possible role of neuropilin-1/β1 integrin endocytosis and focal adhesion kinase degradation.Glycobiology · 2023Article
- The Sea CucumberJournal of natural products · 2023Article
- Structure, anti-SARS-CoV-2, and anticoagulant effects of two sulfated galactans from the red alga Botryocladia occidentalis.International journal of biological macromolecules · 2023Article
- Antiviral activity of marine sulfated glycans against pathogenic human coronaviruses.Scientific reports · 2023Article
- Interactions of marine sulfated glycans with antithrombin and platelet factor 4.Frontiers in molecular biosciences · 2022Article
- Structural and kinetic analyses of holothurian sulfated glycans suggest potential treatment for SARS-CoV-2 infection.The Journal of biological chemistry · 2021Article
- Extracellular Vesicle Signatures and Post-Translational Protein Deimination in Purple Sea Urchin (Biology · 2021Article
- Antiviral activities of four marine sulfated glycans against adenovirus and human cytomegalovirus.Antiviral research · 2021Article
- Fucosylated Chondroitin Sulfates from the Sea CucumbersMarine drugs · 2020Article
- A Glycosaminoglycan-Rich Fraction from Sea CucumberNutrients · 2020Article
- Antithrombotics from the Sea: Polysaccharides and Beyond.Marine drugs · 2019Review
- Structure and Anti-Inflammatory Activity of a New Unusual Fucosylated Chondroitin Sulfate fromMarine drugs · 2018Article
- The Sea as a Rich Source of Structurally Unique Glycosaminoglycans and Mimetics.Microorganisms · 2017Review
- Marine Non-Glycosaminoglycan Sulfated Glycans as Potential Pharmaceuticals.Pharmaceuticals (Basel, Switzerland) · 2015Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Based on considered achievements of the last 25 years, specific combinations of sulfation patterns and glycosylation types have been proved to be key structural players for the anticoagulant activity of certain marine glycans. These conclusions were obtained from comparative and systematic analyses on the structure-anticoagulation relationships of chemically well-defined sulfated polysaccharides of marine invertebrates and red algae. These sulfated polysaccharides are known as sulfated fucans (SFs), sulfated galactans (SGs) and glycosaminoglycans (GAGs). The structural combinations necessary for the anticoagulant activities are the 2-sulfation in α-L-SGs, the 2,4-di-sulfation in α-L-fucopyranosyl units found as composing units of certain sea-urchin and sea-cucumber linear SFs, or as branching units of the fucosylated chondroitin sulfate, a unique GAG from sea-cucumbers. Another unique GAG type from marine organisms is the dermatan sulfate isolated from ascidians. The high levels of 4-sulfation at the galactosamine units combined with certain levels of 2-sulfation at the iduronic acid units is the anticoagulant structural requirements of these GAGs. When the backbones of red algal SGs are homogeneous, the anticoagulation is proportionally dependent of their sulfation content. Finally, 4-sulfation was observed to be the structural motif required to enhance the inhibition of thrombin via heparin cofactor-II by invertebrate SFs.
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