ReviewFrontiers in cellular and infection microbiology2014
Uncovering the components of the Francisella tularensis virulence stealth strategy.
Review in Frontiers in cellular and infection microbiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
34 citing papers in PubMed, 59 citations in OpenAlex.
- De Novo Design of High-Affinity Miniprotein Binders Targeting Francisella Tularensis Virulence Factor.Angewandte Chemie (International ed. in English) · 2025Article
- Animal modelling with theMicrobiology (Reading, England) · 2025Article
- Virulence and genome analysis of three historicalFrontiers in cellular and infection microbiology · 2025Article
- Pathogenicity and virulence ofVirulence · 2023Review
- Comparative analysis of absent in melanoma 2-inflammasome activation inFrontiers in microbiology · 2023Article
- Why vary what's working? Phase variation and biofilm formation inFrontiers in microbiology · 2022Review
- The Biosynthetic Pathway of Ubiquinone Contributes to Pathogenicity of Francisella novicida.Journal of bacteriology · 2021Article
- Review
- Type VI Secretion System and Its Effectors PdpC, PdpD, and OpiA Contribute toInfection and immunity · 2021Article
- Nlrp3 Increases the Host's Susceptibility to Tularemia.Frontiers in microbiology · 2021Article
- Phase Variation of LPS and Capsule Is Responsible for Stochastic Biofilm Formation inFrontiers in cellular and infection microbiology · 2021Article
- Development, Phenotypic Characterization and Genomic Analysis of aFrontiers in microbiology · 2021Article
- Using affinity propagation clustering for identifying bacterial clades and subclades with whole-genome sequences of Francisella tularensis.PLoS neglected tropical diseases · 2020Article
- XFEL and NMR Structures of Francisella Lipoprotein Reveal Conformational Space of Drug Target against Tularemia.Structure (London, England : 1993) · 2020Article
- Survival of the Fittest: The Relationship of (p)ppGpp With Bacterial Virulence.Frontiers in microbiology · 2020Review
- A predictedVirulence · 2019Article
- Contributions of TolC Orthologs toInfection and immunity · 2019Article
- Aerosol prime-boost vaccination provides strong protection in outbred rabbits against virulent type A Francisella tularensis.PloS one · 2018Article
- Article
- RevisitingFrontiers in microbiology · 2018Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Over the last decade, studies on the virulence of the highly pathogenic intracellular bacterial pathogen Francisella tularensis have increased dramatically. The organism produces an inert LPS, a capsule, escapes the phagosome to grow in the cytosol (FPI genes mediate phagosomal escape) of a variety of host cell types that include epithelial, endothelial, dendritic, macrophage, and neutrophil. This review focuses on the work that has identified and characterized individual virulence factors of this organism and we hope to highlight how these factors collectively function to produce the pathogenic strategy of this pathogen. In addition, several recent studies have been published characterizing F. tularensis mutants that induce host immune responses not observed in wild type F. tularensis strains that can induce protection against challenge with virulent F. tularensis. As more detailed studies with attenuated strains are performed, it will be possible to see how host models develop acquired immunity to Francisella. Collectively, detailed insights into the mechanisms of virulence of this pathogen are emerging that will allow the design of anti-infective strategies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.