Evidence map›Paper›PMID 24639778›Full record

ArticleIranian journal of reproductive medicine2013

The frequency of Yq microdeletion in azoospermic and oligospermic Iranian infertile men.

Mohammad Ali Zaimy, Seyyed Mehdi Kalantar, Mohammad Hasan Sheikhha, Tahere Jahaninejad, Hossein Pashaiefar, Jalal Ghasemzadeh, Mahnaz Zahraei

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In one paragraph

Article in Iranian journal of reproductive medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 22 citations in OpenAlex.

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  10. Frequency ofInternational journal of reproductive biomedicine · 2017
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4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Mohammad Ali ZaimyResearch and Clinical Center for Infertility, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. ; Department of Genetics, Faculty of Medical Sciences, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Seyyed Mehdi KalantarResearch and Clinical Center for Infertility, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. ; Department of Genetics, Faculty of Medical Sciences, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Mohammad Hasan SheikhhaResearch and Clinical Center for Infertility, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. ; Department of Genetics, Faculty of Medical Sciences, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Tahere JahaninejadDepartment of Genetics, Faculty of Medical Sciences, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Hossein PashaiefarDepartment of Genetics, Faculty of Medical Sciences, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Jalal GhasemzadehResearch and Clinical Center for Infertility, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Mahnaz ZahraeiDepartment of Genetics, Faculty of Medical Sciences, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Shahid Sadoughi University of Medical Sciences and Health Services · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAbout 15% of couples have infertility problems which 40% of them are related to the male factors. Genetic factors are candidate for about 10% of male infertility conditions. Among these, AZFa, AZFb, AZFc and AZFd regions on the Yq are considered most important for spermatogenesis. Microdeletions of these regions are thought to be involved in some cases of azoospermic or oligospermic infertile men.

objectiveWe studied the prevalence of AZF microdeletions among Iranian infertile men with non-obstructive azoospermia and oligospermia. MATERIALS AND

methodsA total of 50 Iranian azoospermic and oligospermic infertile men were selected for case group and 50 men with normal spermogram as control group. The molecular study of Y chromosome microdeletions was done by multiplex polymerase chain reaction (M-PCR) method by using of 13 sequence tagged site (STS) markers from AZF region.

resultsFour (8%) patients showed Y chromosome microdeletions among case group, deletion in AZFc region was the most frequent (80%) followed by AZFb (20%), in AZFa and AZFd region we did not detect any deletions. No deletion was detected in control group; the ratio of Y chromosome microdeletion in azoospermic men was higher than this ratio in oligospermic men [19% (3/16) among azoospermic men and 3% (1/34) among oligospermics]. Serum FSH level in men with microdeletions was higher than this level in men with no deletions (p=0.034).

conclusionBecause of relatively high prevalence of microdeletions on the long arm of Y chromosome among Iranian azoospermic and oligospermic patients, screening of this microdeletion may be advised to infertile men particularly azoospermic and oligospermic men before using assisted reproductive treatments.

Indexed as

AZF microdeletionMale infertilityMultiplex polymerase chain reaction

Identifiers

PMID24639778
PMCPMC3941317
OpenAlexW1439225493

What OpenQuestion holds

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Registered trials

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