ArticleFrontiers in endocrinology2014
A comparison of anthropometric, metabolic, and reproductive characteristics of young adult women from opposite-sex and same-sex twin pairs.
Article in Frontiers in endocrinology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed, 16 citations in OpenAlex.
- Epigenetic consequences of hormonal interactions between opposite-sex twin fetuses.Clinical and translational medicine · 2020Article
- Testing the twin testosterone transfer hypothesis-intergenerational analysis of 317 dizygotic twins born in Aberdeen, Scotland.Human reproduction (Oxford, England) · 2020Article
- Opposite-sex and same-sex twin studies of physiological, cognitive and behavioral traits.Neuroscience and biobehavioral reviews · 2020Review
- FinnTwin12 Cohort: An Updated Review.Twin research and human genetics : the official journal of the International Society for Twin Studies · 2019Review
- Early-life mortality risks in opposite-sex and same-sex twins: a Danish cohort study of the twin testosterone transfer hypothesis.Annals of epidemiology · 2017Article
- Differences in Religiousness in Opposite-Sex and Same-Sex Twins in a Secular Society.Twin research and human genetics : the official journal of the International Society for Twin Studies · 2016Article
- Gene changes may minimize masculinizing and defeminizing influences of exposure to male cotwins in female callitrichine primates.Biology of sex differences · 2016Article
- Risk of Sex-Specific Cancers in Opposite-Sex and Same-Sex Twins in Denmark and Sweden.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2015Article
- Academic performance of opposite-sex and same-sex twins in adolescence: A Danish national cohort study.Hormones and behavior · 2015Article
- Twins and endocrinology.Indian journal of endocrinology and metabolism · 2014Review
- Assessing prenatal and neonatal gonadal steroid exposure for studies of human development: methodological and theoretical challenges.Frontiers in endocrinology · 2014Article
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 3 countries.
Funding
Abstract
backgroundPrenatal exposure to androgens has been linked to masculinization of several traits. We aimed to determine whether putative female intra-uterine exposure to androgens influences anthropometric, metabolic, and reproductive parameters using a twin design.
methodsTwo cohorts of Finnish twins born in 1975-1979 and 1983-1987 formed the basis for the longitudinal FinnTwin16 (FT16) and FinnTwin12 (FT12) studies. Self-reported anthropometric characteristics, disease status, and reproductive history were compared between 679 same-sex (SS) and 789 opposite-sex (OS) female twins (mean age ± SD: 34 ± 1.1) from the wave 5 of data collection in FT16. Serum lipid and lipoprotein subclass concentrations measured by nuclear magnetic resonance spectroscopy were compared in 226 SS and 169 OS female twins (mean age ± SD: 24 ± 2.1) from the wave 4 of data collection in FT12 and FT16.
resultsAnthropometric measures, the prevalence of hypertension and diabetes mellitus type 2 did not differ significantly between females from SS and OS twin pairs at age 34. Similarly, the prevalence of infertility, age at first pregnancy and number of induced and spontaneous abortions did not differ significantly between these two groups of women. The serum lipid and lipoprotein profile did not differ between females from SS and OS twins at age 24.
conclusionWe found no evidence that androgen overexposure of the female fetus affects obesity, metabolic profile, or reproductive health in young adult females. However, these results do not exclude the possibility that prenatal androgen exposure in females could be adversely associated with these phenotypes later in life.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.