ReviewFrontiers in behavioral neuroscience2014
Tactile C fibers and their contributions to pleasant sensations and to tactile allodynia.
Review in Frontiers in behavioral neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03521778 (Fascial Distortion Model Manual Therapy and Painful Shoulder Syndrome), which is not on this map. Cited by 54 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Fascial Distortion Model Manual Therapy and Painful Shoulder Syndrome
Who cites it
54 citing papers in PubMed, 151 citations in OpenAlex.
- Trial
- Toward an Embodied Medicine: A Portable Device with Programmable Interoceptive Stimulation for Heart Rate Variability Enhancement.Sensors (Basel, Switzerland) · 2018Trial
- MASSAG model: Towards an integrative neuroscience framework linking emotional trauma, pain, and mechanisms of force-based manipulations.Neuroscience and biobehavioral reviews · 2026Review
- Development of interoception: the critical role of maternal affective touch in early attachment.Frontiers in neuroscience · 2026Article
- From peripheral initiation to central integration: a narrative review of the antihypertensive mechanisms of acupuncture in regulating autonomic nervous system homeostasis.Frontiers in neuroscience · 2026Review
- Therapeutic Soreness in Manual Therapy for Chronic Neck Pain: A Triphasic Model of Descending Pain Modulation.Journal of pain research · 2026Review
- Touch, temperature, and relief: a multilevel integrative model of hedonic regulation in massage and thermal therapies.Frontiers in physiology · 2026Article
- Psychophysical correlates of labor pain intensity and unpleasantness.Journal of psychosomatic obstetrics and gynaecology · 2025Article
- [Pain modulating systems and manual medicine].Orthopadie (Heidelberg, Germany) · 2025Article
- The dorsal column nuclei scale mechanical sensitivity in naive and neuropathic pain states.Cell reports · 2025Article
- In vivo calcium imaging reveals directional sensitivity of C-low threshold mechanoreceptors.The Journal of physiology · 2025Article
- Havening: a psycho-sensory therapy for enhancing emotional resilience and psycho-emotional wellbeing across the perinatal period.Frontiers in global women's health · 2025Article
- Infant neural sensitivity to affective touch is associated with maternal postpartum depression.Infant behavior & development · 2024Article
- Infant neural sensitivity to affective touch is associated with maternal postpartum depression.bioRxiv : the preprint server for biology · 2024Article
- The Effects of Osteopathic Manipulative Treatment on Brain Activity: A Scoping Review of MRI and EEG Studies.Healthcare (Basel, Switzerland) · 2024Article
- Review
- Simulating the psychological and neural effects of affective touch with soft robotics: an experimental study.Frontiers in robotics and AI · 2024Article
- Spinal neuromodulation using ultra low frequency waveform inhibits sensory signaling to the thalamus and preferentially reduces aberrant firing of thalamic neurons in a model of neuropathic pain.Frontiers in neuroscience · 2024Article
- Article
- Salivary Oxytocin and Antioxidative Response to Robotic Touch in Adults with Autism Spectrum Disorder.International journal of molecular sciences · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In humans converging evidence indicates that affective aspects of touch are signaled by low threshold mechanoreceptive C tactile (CT) afferents. Analyses of electrophysiological recordings, psychophysical studies in denervated subjects, and functional brain imaging, all indicate that CT primary afferents contribute to pleasant touch and provide an important sensory underpinning of social behavior. Considering both these pleasant and social aspects of gentle skin-to-skin contact, we have put forward a framework within which to consider CT afferent coding properties and pathways-the CT affective touch hypothesis. Recent evidence from studies in mice suggests that CTs, when activated, may have analgesic or anxiolytic effects. However, in neuropathic pain conditions, light touch can elicit unpleasant sensations, so called tactile allodynia. In humans, tactile allodynia is associated with reduced CT mediated hedonic touch processing suggesting loss of the normally analgesic effect of CT signaling. We thus propose that the contribution of CT afferents to tactile allodynia is mainly through a loss of their normally pain inhibiting role.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.