ArticleFrontiers in molecular neuroscience2014
Ancient association between cation leak channels and Mid1 proteins is conserved in fungi and animals.
Article in Frontiers in molecular neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 38 citations in OpenAlex.
- The Effects of CaMembranes · 2026Article
- Do Magnesium Ions Have Similar Effects as Calcium Ions on Resting Membrane Potential?Membranes · 2026Article
- Inactivation of the High-Affinity CaInternational journal of molecular sciences · 2025Article
- NALCN/Cch1 channelosome subunits originated in early eukaryotes.The Journal of general physiology · 2025Article
- Stress-induced reduction of sodium leak currents causes social deficits by impairing dorsal dentate gyrus-medial septum glutamatergic projection.Molecular psychiatry · 2025Article
- Article
- The Biphasic Effect of Lipopolysaccharide on Membrane Potential.Membranes · 2025Article
- A tonically active master neuron modulates mutually exclusive motor states at two timescales.Science advances · 2024Article
- Article
- Function and phylogeny support the independent evolution of an ASIC-like Deg/ENaC channel in the Placozoa.Communications biology · 2023Article
- Olfactory Receptor OR7A17 Expression Correlates with All-International journal of molecular sciences · 2021Article
- NaJournal of neural transmission (Vienna, Austria : 1996) · 2021Review
- Structure of voltage-modulated sodium-selective NALCN-FAM155A channel complex.Nature communications · 2020Article
- Structure of the human sodium leak channel NALCN.Nature · 2020Article
- Sodium action potentials in placozoa: Insights into behavioral integration and evolution of nerveless animals.Biochemical and biophysical research communications · 2020Article
- Highly conserved extracellular residues mediate interactions between pore-forming and regulatory subunits of the yeast CaThe Journal of biological chemistry · 2020Article
- The NALCN channel complex is voltage sensitive and directly modulated by extracellular calcium.Science advances · 2020Article
- Molecular and circuit mechanisms mediating circadian clock output in the Drosophila brain.The European journal of neuroscience · 2020Review
- Brain transcriptome changes in the aging Drosophila melanogaster accompany olfactory memory performance deficits.PloS one · 2018Article
- Post-translational processing and membrane translocation of the yeast regulatory Mid1 subunit of the Cch1/VGCC/NALCN cation channel family.The Journal of biological chemistry · 2017Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Neuronal resting potential can tune the excitability of neural networks, affecting downstream behavior. Sodium leak channels (NALCN) play a key role in rhythmic behaviors by helping set, or subtly changing neuronal resting potential. The full complexity of these newly described channels is just beginning to be appreciated, however. NALCN channels can associate with numerous subunits in different tissues and can be activated by several different peptides and second messengers. We recently showed that NALCN channels are closely related to fungal calcium channels, which they functionally resemble. Here, we use this relationship to predict a family of NALCN-associated proteins in animals on the basis of homology with the yeast protein Mid1, the subunit of the yeast calcium channel. These proteins all share a cysteine-rich region that is necessary for Mid1 function in yeast. We validate this predicted association by showing that the Mid1 homolog in Drosophila, encoded by the CG33988 gene, is coordinately expressed with NALCN, and that knockdown of either protein creates identical phenotypes in several behaviors associated with NALCN function. The relationship between Mid1 and leak channels has therefore persisted over a billion years of evolution, despite drastic changes to both proteins and the organisms in which they exist.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.