ArticleEMBO reports2014
UCP4C mediates uncoupled respiration in larvae of Drosophila melanogaster.
Article in EMBO reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 40 citations in OpenAlex.
- Direct quantification of the metabolic heat output of individual Drosophila brains.Cell reports methods · 2026Article
- Convergent elevation of mitochondrial proton leakage improves thermogenesis in honeybees.Molecular biology and evolution · 2026Article
- Coordinated molecular and physiological adaptations enable activity at sub-freezing temperatures in the snow fly Chionea alexandriana.Current biology : CB · 2026Article
- The mitochondrial uncoupling proteins in early-branching animals: comparative analysis and transcriptional response to temperature in the jellyfish Stomolophus sp.2.Journal of bioenergetics and biomembranes · 2025Article
- Elevated ambient temperature reduces fat storage through the FoxO-mediated insulin signaling pathway.PloS one · 2025Article
- Alteration of mitochondrial function in arthropods during arboviruses infection: a review of the literature.Frontiers in physiology · 2025Review
- Antioxidants, oxidative stress and reactive oxygen species in insects exposed to heat.Current research in insect science · 2025Review
- The Power of Drosophila in Modeling Cancer Cachexia.Advances in experimental medicine and biology · 2025Review
- Article
- The Impact of the Angiotensin-Converting Enzyme Inhibitor Lisinopril on Metabolic Rate inInternational journal of molecular sciences · 2024Article
- orsai, the Drosophila homolog of human ETFRF1, links lipid catabolism to growth control.BMC biology · 2022Article
- A late-stage assembly checkpoint of the human mitochondrial ribosome large subunit.Nature communications · 2022Article
- Article
- Mitochondria as a target and central hub of energy division during cold stress in insects.Frontiers in zoology · 2022Review
- Thriving in Oxygen While Preventing ROS Overproduction: No Two Systems Are Created Equal.Frontiers in physiology · 2022Review
- What fuels the fly: Energy metabolism inScience advances · 2021Review
- Origin and Development of the Adipose Tissue, a Key Organ in Physiology and Disease.Frontiers in cell and developmental biology · 2021Review
- Review
- Circadian regulation of mitochondrial uncoupling and lifespan.Nature communications · 2020Article
- FlySilico: Flux balance modeling of Drosophila larval growth and resource allocation.Scientific reports · 2019Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
Abstract
Larvae of Drosophila melanogaster reared at 23°C and switched to 14°C for 1 h are 0.5°C warmer than the surrounding medium. In keeping with dissipation of energy, respiration of Drosophila melanogaster larvae cannot be decreased by the F-ATPase inhibitor oligomycin or stimulated by protonophore. Silencing of Ucp4C conferred sensitivity of respiration to oligomycin and uncoupler, and prevented larva-to-adult progression at 15°C but not 23°C. Uncoupled respiration of larval mitochondria required palmitate, was dependent on Ucp4C and was inhibited by guanosine diphosphate. UCP4C is required for development through the prepupal stages at low temperatures and may be an uncoupling protein.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.