ArticleThe Journal of endocrinology2014
Potential biomarker of metformin action.
Article in The Journal of endocrinology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 21 citations in OpenAlex.
- Improving Type 2 Diabetes Care with Extended-Release Metformin: Real-Life Insights from a Physician Educational Program.Endocrine, metabolic & immune disorders drug targets · 2024Article
- An update on mode of action of metformin in modulation of meta-inflammation and inflammaging.Pharmacological reports : PR · 2022Review
- Functional genomics and metabolomics advance the ethnobotany of the Samoan traditional medicine "matalafi".Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Alterations of Gut Microbiota by Overnutrition Impact Gluconeogenic Gene Expression and Insulin Signaling.International journal of molecular sciences · 2021Review
- The importance of the AMPK gamma 1 subunit in metformin suppression of liver glucose production.Scientific reports · 2020Article
- Metformin Improves Mitochondrial Respiratory Activity through Activation of AMPK.Cell reports · 2019Article
- Quantitative Analysis of NAD Synthesis-Breakdown Fluxes.Cell metabolism · 2018Article
- IRS posttranslational modifications in regulating insulin signaling.Journal of molecular endocrinology · 2018Review
- Towards a systems approach for chronic diseases, based on health state modeling.F1000Research · 2017Article
- Activation of the cAMP-PKA pathway Antagonizes Metformin Suppression of Hepatic Glucose Production.The Journal of biological chemistry · 2016Article
- Current understanding of metformin effect on the control of hyperglycemia in diabetes.The Journal of endocrinology · 2016Review
- Metformin activates AMP-activated protein kinase by promoting formation of the αβγ heterotrimeric complex.The Journal of biological chemistry · 2015Article
- Low concentrations of metformin suppress glucose production in hepatocytes through AMP-activated protein kinase (AMPK).The Journal of biological chemistry · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Metformin is a first-line, anti-diabetic agent prescribed to over 150 million people worldwide. The main effect of metformin is to suppress glucose production in the liver; however, there is no reliable biomarker to assess the effectiveness of metformin administration. Our previous studies have shown that phosphorylation of CBP at S436 is important for the regulation of hepatic glucose production by metformin. In current study, we found that CBP could be phosphorylated in white blood cells (WBCs), and CBP phosphorylation in the liver and in WBCs of mice had a similar pattern of change during a fasting time course experiment. These data suggests that CBP phosphorylation in WBCs may be used as a biomarker of metformin action in the liver.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.