ArticleMolecular biotechnology2014
Human papillomavirus type 16 pseudovirions with few point mutations in L1 major capsid protein FG loop could escape actual or future vaccination for potential use in gene therapy.
Article in Molecular biotechnology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed, 14 citations in OpenAlex.
- The polymorphism analysis and epitope predicted of Alphapapillomavirus 9 E6 in Sichuan, China.Virology journal · 2022Article
- The possible regions to design Human Papilloma Viruses vaccine in Iranian L1 protein.Biologia · 2020Article
- Rational design of a triple-type human papillomavirus vaccine by compromising viral-type specificity.Nature communications · 2018Article
- Phylogeny and polymorphism in the long control regions E6, E7, and L1 of HPV Type 56 in women from southwest China.Molecular medicine reports · 2018Article
- An Infrared Dye-Conjugated Virus-like Particle for the Treatment of Primary Uveal Melanoma.Molecular cancer therapeutics · 2018Article
- Article
- L1 and L2 gene polymorphisms in HPV-58 and HPV-33: implications for vaccine design and diagnosis.Virology journal · 2016Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
HPV prophylactic vaccination based on VLPs was implemented 7 years ago and has now shown a high degree of efficiency to reduce HPV-induced lesions. Moreover, it was shown that HPV-derived virus-like particles or pseudovirions could be used as gene therapy vectors. As a consequence, characterization of the antigenic structure of HPV capsids is crucial for designing future HPV vaccines with better or broader efficacy and for the design of HPV-derived gene therapy vectors with reduced immunogenicity or vaccination escaping. In this study, we have generated 10 HPV16 FG loop L1 protein mutants and analyzed their ability to self-assemble into VLP, their immunogenicity, and their ability to transduce cells when used as pseudovirions. Most of the mutants had lost their ability to transduce cells at the exception of two chimeric HPV16/31 L1 protein FG loop mutants. Sera from mice immunized with HPV16 L1 wt VLPs very weakly neutralized pseudovirions derived from these two HPV16/31 L1 protein FG loop mutants. These findings suggest that only a few point substitutions within the FG loop are sufficient to generate a new serotype escaping vaccination. As a consequence, derived pseudovirions might be suitable as gene therapy vectors in vaccinated subjects.
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