Evidence map›Paper›PMID 24639297›Full record

ArticleThe American journal of tropical medicine and hygiene2014

Using mitochondrial genome sequences to track the origin of imported Plasmodium vivax infections diagnosed in the United States.

Priscila T Rodrigues, João Marcelo P Alves, Ana María Santamaria, José E Calzada, Maniphet Xayavong, Monica Parise, Alexandre J da Silva, Marcelo U Ferreira

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The American journal of tropical medicine and hygiene, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed.

  1. Article
  2. Article
  3. Parasitology · 2025
    Article
  4. Review
  5. Article
  6. Malaria Genomics, Vaccine Development, and Microbiome.Pathogens (Basel, Switzerland) · 2023
    Review
  7. Article
  8. Article
  9. A PCR-RFLP Technique to Assess the Geographic Origin ofTropical medicine and infectious disease · 2022
    Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Priscila T RodriguesDepartment of Parasitology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil; Department of Parasitology, Gorgas Memorial Institute of Health, Panama City, Panama; Center for Global Health, Division of Parasitic Diseases and Malaria, Centers for Disease Control and Prevention, Atlanta, Georgia.
João Marcelo P AlvesDepartment of Parasitology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil; Department of Parasitology, Gorgas Memorial Institute of Health, Panama City, Panama; Center for Global Health, Division of Parasitic Diseases and Malaria, Centers for Disease Control and Prevention, Atlanta, Georgia.
Ana María SantamariaDepartment of Parasitology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil; Department of Parasitology, Gorgas Memorial Institute of Health, Panama City, Panama; Center for Global Health, Division of Parasitic Diseases and Malaria, Centers for Disease Control and Prevention, Atlanta, Georgia.
José E CalzadaDepartment of Parasitology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil; Department of Parasitology, Gorgas Memorial Institute of Health, Panama City, Panama; Center for Global Health, Division of Parasitic Diseases and Malaria, Centers for Disease Control and Prevention, Atlanta, Georgia.
Maniphet XayavongDepartment of Parasitology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil; Department of Parasitology, Gorgas Memorial Institute of Health, Panama City, Panama; Center for Global Health, Division of Parasitic Diseases and Malaria, Centers for Disease Control and Prevention, Atlanta, Georgia.
Monica PariseDepartment of Parasitology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil; Department of Parasitology, Gorgas Memorial Institute of Health, Panama City, Panama; Center for Global Health, Division of Parasitic Diseases and Malaria, Centers for Disease Control and Prevention, Atlanta, Georgia.
Alexandre J da SilvaDepartment of Parasitology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil; Department of Parasitology, Gorgas Memorial Institute of Health, Panama City, Panama; Center for Global Health, Division of Parasitic Diseases and Malaria, Centers for Disease Control and Prevention, Atlanta, Georgia.
Marcelo U FerreiraDepartment of Parasitology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil; Department of Parasitology, Gorgas Memorial Institute of Health, Panama City, Panama; Center for Global Health, Division of Parasitic Diseases and Malaria, Centers for Disease Control and Prevention, Atlanta, Georgia muferrei@usp.br.

Funding

Population structure and transmission dynamics of Plasmodium vivaxR01AI075416 · NIAID · UNIVERSITY OF SAO PAULO · PI FERREIRA, MARCELO URBANO · 2008 to 2011
$314k
NIAID NIH HHS R01 AI 075416NIAID NIH HHS R01 AI075416
6 · The paper itself

Abstract

Although the geographic origin of malaria cases imported into the United States can often be inferred from travel histories, these histories may be lacking or incomplete. We hypothesized that mitochondrial haplotypes could provide region-specific molecular barcodes for tracing the origin of imported Plasmodium vivax infections. An analysis of 348 mitochondrial genomes from worldwide parasites and new sequences from 69 imported malaria cases diagnosed across the United States allowed for a geographic assignment of most infections originating from the Americas, southeast Asia, east Asia, and Melanesia. However, mitochondrial lineages from Africa, south Asia, central Asia, and the Middle East, which altogether contribute the vast majority of imported malaria cases in the United States, were closely related to each other and could not be reliably assigned to their geographic origins. More mitochondrial genomes are required to characterize molecular barcodes of P. vivax from these regions.

Indexed as

Population SurveillanceBase SequenceBayes TheoremGenome, MitochondrialGenome, ProtozoanHaplotypesHumansMalaria, VivaxMolecular Sequence DataPhylogenyPlasmodium vivaxSequence Analysis, DNASpecies SpecificityTravelUnited States

Identifiers

PMID24639297
PMCPMC4047736

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.