ArticleThe Journal of comparative neurology2014
Postsynaptic distribution of IRSp53 in spiny excitatory and inhibitory neurons.
Article in The Journal of comparative neurology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 51 citations in OpenAlex.
- Single-cell RNA sequencing reveals the immune features and viral tropism in the central nervous system of mice infected with Japanese encephalitis virus.Journal of neuroinflammation · 2024Article
- The PFC-LH-VTA pathway contributes to social deficits in IRSp53-mutant mice.Molecular psychiatry · 2023Article
- Review
- Suppressed prefrontal neuronal firing variability and impaired social representation in IRSp53-mutant mice.eLife · 2022Article
- Adult re-expression of IRSp53 rescues NMDA receptor function and social behavior in IRSp53-mutant mice.Communications biology · 2022Article
- IRSp53 promotes postsynaptic density formation and actin filament bundling.The Journal of cell biology · 2022Article
- Hyperactive ACC-MDT Pathway Suppresses Prepulse Inhibition in Mice.Schizophrenia bulletin · 2021Article
- Revisiting I-BAR Proteins at Central Synapses.Frontiers in neural circuits · 2021Review
- IRSp53 Deletion in Glutamatergic and GABAergic Neurons and in Male and Female Mice Leads to Distinct Electrophysiological and Behavioral Phenotypes.Frontiers in cellular neuroscience · 2020Article
- Postsynaptic densities fragment into subcomplexes upon sonication.Molecular brain · 2019Article
- IRTKS Promotes Insulin Signaling Transduction through Inhibiting SHIP2 Phosphatase Activity.International journal of molecular sciences · 2019Article
- Lhx1/5 control dendritogenesis and spine morphogenesis of Purkinje cells via regulation of Espin.Nature communications · 2017Article
- Article
- Streptozotocin Intracerebroventricular-Induced Neurotoxicity and Brain Insulin Resistance: a Therapeutic Intervention for Treatment of Sporadic Alzheimer's Disease (sAD)-Like Pathology.Molecular neurobiology · 2016Review
- The Postsynaptic Density: There Is More than Meets the Eye.Frontiers in synaptic neuroscience · 2016Article
- Article
- Organization of TNIK in dendritic spines.The Journal of comparative neurology · 2015Article
- The organization of AMPA receptor subunits at the postsynaptic membrane.Hippocampus · 2015Article
- Quantitative mass spectrometry measurements reveal stoichiometry of principal postsynaptic density proteins.Journal of proteome research · 2015Article
- Social deficits in IRSp53 mutant mice improved by NMDAR and mGluR5 suppression.Nature neuroscience · 2015Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
The 53 kDa insulin receptor substrate protein (IRSp53) is highly enriched in the brain. Despite evidence that links mutations of IRSp53 with autism and other neuropsychiatric problems, the functional significance of this protein remains unclear. We used light and electron microscopic immunohistochemistry to demonstrate that IRSp53 is expressed throughout the adult rat brain. Labeling concentrated selectively in dendritic spines, where it was associated with the postsynaptic density (PSD). Surprisingly, its organization within the PSD of spiny excitatory neurons of neocortex and hippocampus differed from that within spiny inhibitory neurons of neostriatum and cerebellar cortex. The present data support previous suggestions that IRSp53 is involved in postsynaptic signaling, while hinting that its signaling role may differ in different types of neurons.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.