ArticleSocial psychiatry and psychiatric epidemiology2014
Record-linkage studies of the coexistence of epilepsy and bipolar disorder.
Article in Social psychiatry and psychiatric epidemiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Safety and recommendations for TMS use in healthy subjects and patient populations, with updates on training, ethical and regulatory issues: Expert Guidelines.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2021Guideline
- Abnormal patterns of sleep and waking behaviors are accompanied by neocortical oscillation disturbances in an Ank3 mouse model of epilepsy-bipolar disorder comorbidity.Translational psychiatry · 2023Article
- Mood and Anxiety Disorders and Suicidality in Patients With Newly Diagnosed Focal Epilepsy: An Analysis of a Complex Comorbidity.Neurology · 2023Article
- Hippocampal Pathophysiology: Commonality Shared by Temporal Lobe Epilepsy and Psychiatric Disorders.Neuroscience journal · 2018Review
- Ankyrin-G isoform imbalance and interneuronopathy link epilepsy and bipolar disorder.Molecular psychiatry · 2017Article
- Big data for bipolar disorder.International journal of bipolar disorders · 2016Review
- Major depressive disorder, suicidal behaviour, bipolar disorder, and generalised anxiety disorder among emerging adults with and without chronic health conditions.Epidemiology and psychiatric sciences · 2016Article
- The association of mood disorders with breast cancer survival: an investigation of linked cancer registration and hospital admission data for South East England.Psycho-oncology · 2016Article
- Parental and comorbid epilepsy in persons with bipolar disorder.Journal of affective disorders · 2015Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeInterest is growing in a possible link between epilepsy and bipolar disorder (BPD). We used two large datasets of hospital admission data to determine whether epilepsy and BPD occur together in the same individuals more commonly than expected.
methodsWe undertook retrospective cohort studies using the Oxford Record Linkage Study (ORLS) and English national linked Hospital Episode Statistics. We constructed a cohort of people in each dataset admitted with epilepsy (without prior admission for BPD), and a control cohort (without prior admission for BPD), and compared their subsequent admission rates for BPD. Conversely, we constructed a cohort of people in each dataset admitted with BPD and a control cohort (both without prior admission for epilepsy), and compared their subsequent admission rates for epilepsy.
resultsIn the epilepsy cohort, compared with the control cohort, the rate ratio (RR) for BPD was significantly high at 3.0 (95 % confidence interval 1.7-5.1) in the ORLS and 3.6 (3.3-3.9) in the all-England dataset. In the BPD cohort, the RR for epilepsy was 2.2 (1.2-3.7) in the ORLS and 4.2 (4.0-4.4) in the all-England cohort. We found no significant differences between RRs for males and females.
conclusionsEpilepsy and BPD occur together in individuals more frequently than expected by chance.
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Registered trials
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