ArticleMolecules (Basel, Switzerland)2014
Extract from Armoracia rusticana and its flavonoid components protect human lymphocytes against oxidative damage induced by hydrogen peroxide.
Article in Molecules (Basel, Switzerland), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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10 citing papers in PubMed, 33 citations in OpenAlex.
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- Root Vegetables-Composition, Health Effects, and Contaminants.International journal of environmental research and public health · 2022Review
- In Vitro Antioxidant and Bactericidal Efficacy of 15 Common Spices: Novel Therapeutics for Urinary Tract Infections?Medicina (Kaunas, Lithuania) · 2019Article
- Human Lymphocyte-Protective Effects of an Ethanol Extract fromAntioxidants (Basel, Switzerland) · 2018Article
- Comparison of lymphocyte DNA damage levels and total antioxidant capacity in Korean and American diet.Nutrition research and practice · 2017Article
- Hyperforin Exhibits Antigenotoxic Activity on Human and Bacterial Cells.Molecules (Basel, Switzerland) · 2017Article
- Evaluation of an Aqueous Extract from Horseradish Root (Evidence-based complementary and alternative medicine : eCAM · 2017Article
- Antioxidant effects and protective potential of fruit extracts ofAvicenna journal of phytomedicineArticle
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6 authors at 1 institution in 1 country.
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Abstract
DNA damage prevention is an important mechanism involved in cancer prevention by dietary compounds. Armoracia rusticana is cultivated mainly for its roots that are used in the human diet as a pungent spice. The roots represent rich sources of biologically active phytocompounds, which are beneficial for humans. In this study we investigated the modulation of H₂O₂ genotoxicity using the A. rusticana root aqueous extract (AE) and two flavonoids (kaempferol or quercetin). Human lymphocytes pre-treated with AE, kaempferol and quercetin were challenged with H₂O₂ and the DNA damage was assessed by the comet assay. At first we assessed a non-genotoxic concentration of AE and flavonoids, respectively. In lymphocytes challenged with H₂O₂ we proved that the 0.0025 mg·mL⁻¹ concentration of AE protected human DNA. It significantly reduced H₂O₂-induced oxidative damage (from 78% to 35.75%). Similarly, a non-genotoxic concentration of kaempferol (5 μg·mL⁻¹) significantly diminished oxidative DNA damage (from 83.3% to 19.4%), and the same concentration of quercetin also reduced the genotoxic effect of H₂O₂ (from 83.3% to 16.2%). We conclude that AE, kaempferol and quercetin probably act as antimutagens. The molecular mechanisms underlying their antimutagenic activity might be explained by their antioxidant properties.
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