ArticleAmerican journal of hypertension2014
Impact of central obesity on the estimation of carotid-femoral pulse wave velocity.
Article in American journal of hypertension, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The effect of aerobic exercise on pulse wave velocity in middle-aged and elderly people: A systematic review and meta-analysis of randomized controlled trials.Frontiers in cardiovascular medicine · 2022Pooled it
- 2024 Recommendations for Validation of Noninvasive Arterial Pulse Wave Velocity Measurement Devices.Hypertension (Dallas, Tex. : 1979) · 2024Article
- Age-related values of aortic pulse wave velocity in healthy subjects measured by Doppler echocardiography.Journal of human hypertension · 2021Article
- Effects of Exercise and Weight Loss on Proximal Aortic Stiffness in Older Adults With Obesity.Circulation · 2021Article
- Increased arterial stiffness in males with abdominal aortic aneurysm.Clinical physiology and functional imaging · 2021Article
- Article
- Influence of Body Composition on Arterial Stiffness in Middle-Aged Adults: Healthy UAL Cross-Sectional Study.Medicina (Kaunas, Lithuania) · 2019Article
- Short- and Long-Term Effects of Bariatric Surgery on Vascular Phenotype.Obesity surgery · 2019Observational
- Determinants of pulse wave velocity trajectories from youth to young adulthood: the Georgia Stress and Heart Study.Journal of hypertension · 2019Article
- Contribution of Type 2 Diabetes Mellitus to Subclinical Atherosclerosis in Subjects with Morbid Obesity.Obesity surgery · 2018Article
- Adiposity measures and arterial stiffness in primary care: the MARK prospective observational study.BMJ open · 2017Observational
- Ethnic Differences in and Childhood Influences on Early Adult Pulse Wave Velocity: The Determinants of Adolescent, Now Young Adult, Social Wellbeing, and Health Longitudinal Study.Hypertension (Dallas, Tex. : 1979) · 2016Article
- Adiposity, obesity, and arterial aging: longitudinal study of aortic stiffness in the Whitehall II cohort.Hypertension (Dallas, Tex. : 1979) · 2015Article
- Regional variations in the relationship between arterial stiffness and adipocyte volume or number in obese subjects.International journal of obesity (2005) · 2015Article
- Role of bone mineral density in the inverse relationship between body size and aortic calcification: results from the Baltimore Longitudinal Study of Aging.Atherosclerosis · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
backgroundStudies have found that central obesity is associated with higher carotid-femoral pulse wave velocity (PWV). However, traveled distance (TD) measured over the body surface can be substantially overestimated with wider waist circumference (WC). We sought to investigate whether central obesity biases the estimation of PWV and whether this bias explains the association between PWV and different measures of adiposity.
methodsSeven hundred eleven participants (49.5% men) from the Baltimore Longitudinal Study of Aging with PWV, anthropometrics, and quantification of different fat depots by computed tomography and dual x-ray absorptiometry were included. TD and relative PWV were estimated with a tape measure over the body surface or linear distances taken from radiological images, unaffected by obesity.
resultsA significant association was found between wider WC and a greater difference between the 2 TD measurements and their respective PWV in both sexes (r ≥ 0.34; P < 0.001). This overestimation bias appeared to be generally higher in women than men (0.27 m/sec for each unit increase in WC; P < 0.0001). When TD estimated over the body surface was used to calculate PWV, greater WC, total body fat, subcutaneous fat, and visceral fat were all associated with higher PWV (P < 0.05 for all). However, when PWV was calculated using TD estimated from radiological images or body height, only the association with visceral fat held significant.
conclusionsWhen TD is measured over the body surface, the role of obesity on PWV is substantially overestimated. After accounting for this bias, PWV was still independently associated with visceral fat but not with other measures of adiposity, confirming its contribution to arterial stiffening.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.