ArticleTransplantation2014
Pulsatile perfusion reduces the risk of delayed graft function in deceased donor kidney transplants, irrespective of donor type and cold ischemic time.
Article in Transplantation, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 1 of them a synthesis that pooled it.
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Who cites it
40 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- Hypothermic Machine Perfusion in Deceased Donor Kidney Transplantation: Provider and Transplant Center Practices and Perspectives.Clinical transplantation · 2026Article
- Delayed graft function and long-term outcomes after deceased donor kidney transplantation: insights from mate-kidney analysis.Transplant international : official journal of the European Society for Organ Transplantation · 2026Article
- Hypothermic Perfusion Mitigates Extended Cold Ischemia Time in Kidney Transplantation.Clinical journal of the American Society of Nephrology : CJASN · 2026Article
- Hypothermic Machine Perfusion vs. Static Cold Storage in Kidney Transplantation: A Retrospective Paired-Kidney Study from Latvia.Medicina (Kaunas, Lithuania) · 2025Article
- Does Oxygen Work? Evidence for Oxygenation During Kidney Graft Preservation: A Review.Journal of clinical medicine · 2025Review
- Nationwide Hypothermic Machine Perfusion for ECD and DCD Kidney Transplantation in Belgium: One-Year Outcomes and Impact on Transplant Rates and Budget Impact Analysis.Transplant international : official journal of the European Society for Organ Transplantation · 2025Article
- The Evolution of Kidney Graft Preservation Through the Years.Life (Basel, Switzerland) · 2024Review
- Mechanical Preservation and Delayed Graft Function and Hospital Length of Stay as Deployed in the United States: Analysis of the Last Decade.Annals of transplantation · 2024Article
- Role of necroptosis in kidney health and disease.Nature reviews. Nephrology · 2023Review
- Dynamic Parameters of Hypothermic Machine Perfusion-An Image of Initial Graft Function in Adult Kidney Transplantation?Journal of clinical medicine · 2022Article
- Progress and Setbacks in Translating a Decade of Ferroptosis Research into Clinical Practice.Cells · 2022Review
- Intraoperative Verapamil Fails to Reduce Delayed Graft Function in Donation After Circulatory Death Renal Allografts.Transplantation direct · 2022Article
- Effect of Long Cold Ischemia Time of Kidneys from Aged Donors on Prognosis of Kidney Transplantation.Annals of transplantation · 2021Review
- Aorto-Iliac Artery Calcification and Graft Outcomes in Kidney Transplant Recipients.Journal of clinical medicine · 2021Article
- Minimizing Ischemia Reperfusion Injury in Xenotransplantation.Frontiers in immunology · 2021Review
- [Machine perfusion for conditioning liver and kidneys before transplantation].Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen · 2020Review
- Polyethylene Glycol 35 as a Perfusate Additive for Mitochondrial and Glycocalyx Protection in HOPE Liver Preservation.International journal of molecular sciences · 2020Review
- A Retrospective Propensity Score Matched Analysis Reveals Superiority of Hypothermic Machine Perfusion over Static Cold Storage in Deceased Donor Kidney Transplantation.Journal of clinical medicine · 2020Article
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5 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundThe role of pulsatile perfusion (PP) across different cold ischemic times (CIT) within different donor groups is unclear. This study examined the association of PP with delayed graft function (DGF) in all (n=94,709) deceased donor kidney transplants in the US between 2000 and 2011, as a function of CIT and donor type.
methodsUsing the Scientific Registry of Transplant Recipients data, all adult standard criteria donors (SCD, n=71,192), expanded criteria donors (ECD, n=15,122), and donors after circulatory death (DCD, n=8,395) kidney transplant recipients were identified. Within each donor group, transplants were stratified based on duration of CIT: 0 to 6 hours, 6.1 to 12 hours, 12.1 to 18 hours, 18.1 to 24 hours, 24.1 to 30 hours, 30.1 to 36 hours, and greater than 36 hours. Within each group, the odds of DGF with and without PP was determined after adjusting for donor, recipient, and transplant factors, including a propensity score for the likelihood of PP use, and clustering on transplant center using multivariable logistic regression.
resultsWhen stratified by donor type and CIT, the adjusted odds of DGF were lower with PP across all CIT in SCD transplants, when CIT was greater than 6 hours in ECD transplants, and when CIT was between 6 and 24 hours in DCD transplants. CIT was independently associated with a greater risk of DGF irrespective of storage method, but this effect was substantially modified by PP.
conclusionPP is associated with a reduced risk of DGF irrespective of donor type and CIT. Although PP modifies the impact of CIT on the risk of DGF, it does not eliminate its association with DGF, suggesting the optimal strategy to reduce DGF is to minimize CIT and utilize PP in all deceased donor transplants.
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