Evidence map›Paper›PMID 24637752›Full record

ArticleActa crystallographica. Section F, Structural biology communications2014

Preliminary X-ray crystallographic analysis of glutathione transferase zeta 1 (GSTZ1a-1a).

Christopher D Boone, Guo Zhong, Marci Smeltz, Margaret O James, Robert McKenna

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta crystallographica. Section F, Structural biology communications, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Age-Related Changes in Expression and Activity of Human Hepatic Mitochondrial Glutathione Transferase Zeta1.Drug metabolism and disposition: the biological fate of chemicals · 2018
    Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Christopher D BooneDepartment of Biochemistry and Molecular Biology, University of Florida, PO Box 100245, Gainesville, FL 32610, USA.
Guo ZhongDepartment of Medicinal Chemistry, University of Florida, PO Box 100485, Gainesville, FL 32610, USA.
Marci SmeltzDepartment of Medicinal Chemistry, University of Florida, PO Box 100485, Gainesville, FL 32610, USA.
Margaret O JamesDepartment of Medicinal Chemistry, University of Florida, PO Box 100485, Gainesville, FL 32610, USA.
Robert McKennaDepartment of Biochemistry and Molecular Biology, University of Florida, PO Box 100245, Gainesville, FL 32610, USA.
University of Florida · US

Funding

CATALYTIC MECHANISM OF CARBONIC ANHYDRASER01GM025154 · NIGMS · UNIVERSITY OF FLORIDA · PI SILVERMAN, DAVID N · 1985 to 2012
$4.5M
Diversity Supplement to 2RO1 GM 099871R01GM099871 · NIGMS · UNIVERSITY OF FLORIDA · PI JAMES, MARGARET OLIVE, STACPOOLE, PETER WALLACE · 2012 to 2019
$2.7M
NIGMS NIH HHS R01 GM025154NIGMS NIH HHS R01 GM099871
6 · The paper itself

Abstract

Glutathione transferase zeta 1 (GSTZ1-1) is a homodimeric enzyme found in the cytosol and mitochondrial matrix of the liver and other tissues. It catalyzes the glutathione-dependent isomerization of maleylacetoacetate to fumarylacetoacetate in the tyrosine catabolic pathway and can metabolize small halogenated carboxylic acids. GSTZ1a-1a crystals diffracted to a resolution of 3.1 Å and belonged to space group P1, with unit-cell parameters a = 42.0, b = 49.6, c = 54.6 Å, α = 82.9, β = 69.9, γ = 73.4°, with a calculated Matthews coefficient of 2.1 Å(3) Da(-1) assuming a dimer in the crystallographic asymmetric unit. Refinement of the structure is currently in progress.

Indexed as

Crystallography, X-RayGlutathione TransferaseHumansIsoenzymesProtein ConformationGlutathione TransferaseGSTZ1 protein, humanIsoenzymesglutathione transferaseGSTZ1a-1a

Identifiers

PMID24637752
PMCPMC3936459
OpenAlexW2080215104

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.