Evidence map›Paper›PMID 24637631›Full record

ArticlePsychiatric genetics2014

Genetic polymorphisms in glutathione-S-transferases are associated with anxiety and mood disorders in nicotine dependence.

Sandra Odebrecht Vargas Nunes, Márcia Regina Pizzo de Castro, Maria Angelica Ehara Watanabe, Roberta Losi Guembarovski, Heber Odebrecht Vargas, Edna Maria Vissoci Reiche, Helena Kaminami Morimoto, Seetal Dodd, Michael Berk

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In one paragraph

Article in Psychiatric genetics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 19 citations in OpenAlex.

  1. N-acetylcysteine for therapy-resistant tobacco use disorder: a pilot study.Redox report : communications in free radical research · 2015
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 3 countries.

Sandra Odebrecht Vargas NunesaCenter of Approach and Treatment for Smokers, University Hospital, Londrina State University bDepartment of Psychiatry, Health Sciences Center cDepartment of Pathological Sciences, Biological Sciences Center dDepartment of Pathology, Clinical Analysis and Toxicology, Health Sciences Center, Londrina State University, Londrina, Paraná, Brazil eIMPACT Strategic Research Centre, School of Medicine, Deakin University fBarwon Health and the Geelong Clinic, Swanston Centre, Geelong, Victoria gDepartment of Psychiatry, Orygen Youth Health Research Centre, Centre for Youth Mental Health, The Florey Institute for Neuroscience and Mental Health, University of Melbourne, Parkville, Australia.
Márcia Regina Pizzo de Castro
Maria Angelica Ehara Watanabe
Roberta Losi Guembarovski
Heber Odebrecht Vargas
Edna Maria Vissoci Reiche
Helena Kaminami Morimoto
Seetal Dodd
Michael Berk
Universidade Estadual de Londrina · BRBarwon Health · AUFlorey Institute of Neuroscience and Mental Health · AUGTx (United States) · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundNicotine dependence is associated with an increased risk of mood and anxiety disorders and suicide. The primary hypothesis of this study was to identify whether the polymorphisms of two glutathione-S-transferase enzymes (GSTM1 and GSTT1 genes) predict an increased risk of mood and anxiety disorders in smokers with nicotine dependence. MATERIALS AND

methodsSmokers were recruited at the Centre of Treatment for Smokers. The instruments were a sociodemographic questionnaire, Fagerström Test for Nicotine Dependence, diagnoses of mood disorder and nicotine dependence according to DSM-IV (SCID-IV), and the Alcohol, Smoking and Substance Involvement Screening Test. Anxiety disorder was assessed based on the treatment report. Laboratory assessment included glutathione-S-transferases M1 (GSTM1) and T1 (GSTT1), which were detected by a multiplex-PCR protocol.

resultsCompared with individuals who had both GSTM1 and GSTT1 genes, a higher frequency of at least one deletion of the GSTM1 and GSTT1 genes was identified in anxious smokers [odds ratio (OR)=2.21, 95% confidence interval (CI)=1.05-4.65, P=0.034], but there was no association with bipolar and unipolar depression (P=0.943). Compared with nonanxious smokers, anxious smokers had a greater risk for mood disorders (OR=4.67; 95% CI=2.24-9.92, P<0.001), lung disease (OR=6.78, 95% CI=1.95-23.58, P<0.003), and suicide attempts (OR=17.01, 95% CI=2.23-129.91, P<0.006).

conclusionThis study suggests that at least one deletion of the GSTM1 and GSTT1 genes represents a risk factor for anxious smokers. These two genes may modify the capacity for the detoxification potential against oxidative stress.

Indexed as

Genetic Predisposition to DiseasePolymorphism, GeneticAdolescentAdultAnxiety DisordersFemaleGlutathione TransferaseHumansMaleMiddle AgedMood DisordersSmokingSuicide, AttemptedTobacco Use DisorderYoung Adultglutathione S-transferase T1Glutathione Transferase

Identifiers

PMID24637631
PMCPMC4004636
OpenAlexW2094047891

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.