ArticlePloS one2014
Rapid granulation tissue regeneration by intracellular ATP delivery--a comparison with Regranex.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- The role of cluster of differentiation 163-positive macrophages in wound healing: a preliminary study and a systematic review.Archives of dermatological research · 2023Pooled it
- Roles of extracellular adenosine triphosphate on the functions of periodontal ligament cells.BDJ open · 2023Review
- Microenvironment-Based Diabetic Foot Ulcer Nanomedicine.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Review
- ENERGI-F703 gel, as a new topical treatment for diabetic foot and leg ulcers: A multicenter, randomized, double-blind, phase II trial.EClinicalMedicine · 2022Article
- Locally Delivered Metabolite Derivative Promotes Bone Regeneration in Aged Mice.ACS applied bio materials · 2022Article
- A review of biomimetic scaffolds for bone regeneration: Toward a cell-free strategy.Bioengineering & translational medicine · 2021Review
- Enhanced Skin Incisional Wound Healing With Intracellular ATP DeliveryFrontiers in pharmacology · 2021Article
- Bioenergetic-active materials enhance tissue regeneration by modulating cellular metabolic state.Science advances · 2020Article
- Treatment of Posttraumatic Osteoarthritis Secondary to a Chronic Plafond Fracture: A Case Report.Journal of chiropractic medicine · 2019Article
- Intracellular ATP Delivery Causes Rapid Tissue RegenerationFrontiers in pharmacology · 2019Article
- Topical Naltrexone Is a Safe and Effective Alternative to Standard Treatment of Diabetic Wounds.Advances in wound care · 2017Article
- Article
- Macrophage Differentiation in Normal and Accelerated Wound Healing.Results and problems in cell differentiation · 2017Review
- Rapid tissue regeneration induced by intracellular ATP delivery-A preliminary mechanistic study.PloS one · 2017Article
- Two-headed tetraphosphate cap analogs are inhibitors of the Dcp1/2 RNA decapping complex.RNA (New York, N.Y.) · 2016Article
- DAMPs from Cell Death to New Life.Frontiers in immunology · 2015Review
- Platelet-derived growth factor mediates interleukin-13-induced collagen I production in mouse airway fibroblasts.Journal of biosciences · 2014Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
This study tests a new intracellular ATP delivery technique for tissue regeneration and compares its efficacy with that of Regranex. Twenty-seven adult New Zealand white rabbits each underwent minimally invasive surgery to render one ear ischemic. Eight wounds were then created: four on the ischemic and four on the normal ear. Two wounds on one side of each ear were treated with Mg-ATP encapsulated lipid vesicles (ATP-vesicles) while the two wounds on the other side were treated with Regranex. Wound healing time was shorter when ATP-vesicles were used. The most striking finding was that new tissue growth started to appear in less than 1 day when ATP-vesicles were used. The growth continued and covered the wound area within a few days, without the formation of a provisional matrix. Regranex-treated wounds did not have this growth pattern. In wounds treated by ATP-vesicles, histologic studies revealed extremely rich macrophage accumulation, along with active proliferating cell nuclear antigen (PCNA) and positive BrdU staining, indicating in situ macrophage proliferation. Human macrophage culture suggested direct collagen production. These results support an entirely new healing process, which seems to have combined the conventional hemostasis, inflammation, and proliferation phases into a single one, thereby eliminating the lag time usually seen during healing process.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.