ArticleNucleus (Austin, Tex.)
The missing LINC: a mammalian KASH-domain protein coupling meiotic chromosomes to the cytoskeleton.
Article in Nucleus (Austin, Tex.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 26 citations in OpenAlex.
- Heterochromatin in plant meiosis.Nucleus (Austin, Tex.) · 2024Review
- The SUN1-SPDYA interaction plays an essential role in meiosis prophase I.Nature communications · 2021Article
- The Role of the LINC Complex in Sperm Development and Function.International journal of molecular sciences · 2020Review
- Article
- Molecular structure of human synaptonemal complex protein SYCE1.Chromosoma · 2019Article
- Live cell analyses of synaptonemal complex dynamics and chromosome movements in cultured mouse testis tubules and embryonic ovaries.Chromosoma · 2018Article
- Nesprins and Lamins in Health and Diseases of Cardiac and Skeletal Muscles.Frontiers in physiology · 2018Review
- The Nucleoporin Nup2 Contains a Meiotic-Autonomous Region that Promotes the Dynamic Chromosome Events of Meiosis.Genetics · 2017Article
- Telomere homeostasis in mammalian germ cells: a review.Chromosoma · 2016Review
- Mechanism and regulation of rapid telomere prophase movements in mouse meiotic chromosomes.Cell reports · 2015Article
- Macromolecular transport between the nucleus and the cytoplasm: Advances in mechanism and emerging links to disease.Biochimica et biophysica acta · 2014Review
- The intriguing plant nuclear lamina.Frontiers in plant science · 2014Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pairing of homologous chromosome is a unique event in meiosis that is essential for both haploidization of the genome and genetic recombination. Rapid chromosome movements during meiotic prophase are a key feature of the pairing process. This is usually telomere-led, and in metazoans is dependent upon microtubules and dynein. Chromosome movements culminate in the formation of a meiotic "bouquet" in which nuclear envelope-associated telomeres are clustered at the centrosomal pole of the nucleus. Bouquet formation is thought to facilitate homolog pairing. Recent studies reveal that coupling of telomeres to cytoplasmic dynein is mediated by SUN1 in the inner nuclear membrane (INM) and KASH5 a novel protein of the outer nuclear membrane (ONM). Together SUN1 and KASH5 assemble to form a transluminal LINC (linker of the nucleoskeleton and cytoskeleton) complex that spans both nuclear membranes. SUN1 forms attachment sites for telomeres at the INM while KASH5 functions as a dynein adaptor at the ONM. In mice deficient in KASH5, homologous chromosome pairing does not occur. The result is that meiosis is arrested at the leptotene/zygotene stage of meiotic prophase 1, and as a consequence both male and female mice are infertile. This study demonstrates an essential role for dynein directed telomere movement during meiotic prophase.
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