ArticleG3 (Bethesda, Md.)2014
Effects of sample selection bias on the accuracy of population structure and ancestry inference.
Article in G3 (Bethesda, Md.), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed.
- Whole-Genome Resequencing Reveals Exceptions to Panmixia in the Exploited Top Fish Predator Antarctic Toothfish (Ecology and evolution · 2026Article
- The highly heterozygous European amphioxus (Branchiostoma lanceolatum) at the edge of panmixia.PLoS genetics · 2026Article
- Genomic Sampling and Population Structure of Farmer-Maintained Varieties Reveal Previously Uncharacterized Diversity of Theobroma cacao L. in Costa Rica.Molecular ecology · 2026Article
- Interventions for Improving Leisure for Older Adults on the Palliative Pathway Living With Advanced Cancer: A Qualitative Systematic Review.The British journal of occupational therapy · 2026Review
- Whole-genome analysis reveals genetic diversity and selection pressure in Sichuan donkey.BMC genomics · 2025Article
- Is there a female-male self-selection bias in TSST-based reactive stress research?Comprehensive psychoneuroendocrinology · 2025Article
- Reconciling Gene Tree Discordance and Biogeography in European Crows.Molecular ecology · 2025Article
- Development of a Noninvasive Genotyping-In-Thousands (GTseq) Panel for Long-Term Conservation of Western Great Lakes Gray Wolves (Ecology and evolution · 2025Article
- SARS-CoV-2 Variants: Genetic Insights, Epidemiological Tracking, and Implications for Vaccine Strategies.International journal of molecular sciences · 2025Review
- Effect of breed composition in genomic prediction using crossbred pig reference population.Journal of animal science and technology · 2025Article
- Genetic and phenotypic heterogeneity of type 2 diabetes across Russian ancestry groups.Frontiers in endocrinology · 2025Article
- Multilevel Determinants of Long COVID and Potential for Telehealth Intervention.Ethnicity & disease · 2024Article
- The unmet need for mental health support among persons with disabilities in Somalia: Principal correlates and barriers to access.Global mental health (Cambridge, England) · 2024Article
- The role of NOP58 in prostate cancer progression through SUMOylation regulation and drug response.Frontiers in pharmacology · 2024Article
- Genomic and geographical structure of human cytomegalovirus.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Genome-Wide Admixture Mapping Identifies Wild Ancestry-of-Origin Segments in Cultivated Robusta Coffee.Genome biology and evolution · 2023Article
- Comparative analysis of allele variation using allele frequencies according to sample size in Korean population.Genes & genomics · 2021Article
- Article
- Genetic diversity patterns and domestication origin of soybean.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2019Article
- New ABCC2 rs3740066 and rs2273697 Polymorphisms Identified in a Healthy Colombian Cohort.Pharmaceutics · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Population stratification is an important task in genetic analyses. It provides information about the ancestry of individuals and can be an important confounder in genome-wide association studies. Public genotyping projects have made a large number of datasets available for study. However, practical constraints dictate that of a geographical/ethnic population, only a small number of individuals are genotyped. The resulting data are a sample from the entire population. If the distribution of sample sizes is not representative of the populations being sampled, the accuracy of population stratification analyses of the data could be affected. We attempt to understand the effect of biased sampling on the accuracy of population structure analysis and individual ancestry recovery. We examined two commonly used methods for analyses of such datasets, ADMIXTURE and EIGENSOFT, and found that the accuracy of recovery of population structure is affected to a large extent by the sample used for analysis and how representative it is of the underlying populations. Using simulated data and real genotype data from cattle, we show that sample selection bias can affect the results of population structure analyses. We develop a mathematical framework for sample selection bias in models for population structure and also proposed a correction for sample selection bias using auxiliary information about the sample. We demonstrate that such a correction is effective in practice using simulated and real data.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.