ArticleThe Journal of cell biology2014
Dual-mode regulation of the APC/C by CDK1 and MAPK controls meiosis I progression and fidelity.
Article in The Journal of cell biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 34 citations in OpenAlex.
- MOS is a key regulator of meiotic midbody assembly and prevents abnormal divisions in mouse eggs and their polar bodies.Journal of cell science · 2026Article
- Semen Quality, Testicular Cell Apoptosis, and Transcriptome Analysis Following Mild Scrotal Heat Stress in Wugu-Hu Crossbred and Hu Rams.Animals : an open access journal from MDPI · 2025Article
- A non-pheromone GPCR is essential for meiosis and ascosporogenesis in the wheat scab fungus.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Regulation of oocyte maturation: Role of conserved ERK signaling.Molecular reproduction and development · 2022Review
- Bifurcation and oscillatory dynamics of delayed CDK1-APC feedback loop.IET systems biology · 2020Article
- Nampt-mediated spindle sizing secures a post-anaphase increase in spindle speed required for extreme asymmetry.Nature communications · 2020Article
- DPAGT1-Mediated ProteinAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2020Article
- The Error-Prone Kinetochore-Microtubule Attachments During Meiosis I in Vitrified Oocytes.Frontiers in cell and developmental biology · 2020Article
- Progression of Meiosis Is Coordinated by the Level and Location of MAPK Activation Via OGR-2 inGenetics · 2019Article
- Cdk1 inactivation induces post-anaphase-onset spindle migration and membrane protrusion required for extreme asymmetry in mouse oocytes.Nature communications · 2018Article
- Regulation of the meiotic divisions of mammalian oocytes and eggs.Biochemical Society transactions · 2018Review
- MAPK signaling couples SCF-mediated degradation of translational regulators to oocyte meiotic progression.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Maternal age-dependent APC/C-mediated decrease in securin causes premature sister chromatid separation in meiosis II.Nature communications · 2017Article
- Analysis of Chromosome Segregation, Histone Acetylation, and Spindle Morphology in Horse Oocytes.Journal of visualized experiments : JoVE · 2017Article
- The BTG4 and CAF1 complex prevents the spontaneous activation of eggs by deadenylating maternal mRNAs.Open biology · 2016Article
- DNA damage-induced metaphase I arrest is mediated by the spindle assembly checkpoint and maternal age.Nature communications · 2015Article
- An actin-dependent spindle position checkpoint ensures the asymmetric division in mouse oocytes.Nature communications · 2015Article
- The spindle checkpoint and chromosome segregation in meiosis.The FEBS journal · 2015Review
- MAPK3/1 (ERK1/2) and Myosin Light Chain Kinase in Mammalian Eggs Affect Myosin-II Function and Regulate the Metaphase II State in a Calcium- and Zinc-Dependent Manner.Biology of reproduction · 2015Article
- Mastl is required for timely activation of APC/C in meiosis I and Cdk1 reactivation in meiosis II.The Journal of cell biology · 2014Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 3 countries.
Funding
Abstract
Female meiosis is driven by the activities of two major kinases, cyclin-dependent kinase 1 (Cdk1) and mitogen-activated protein kinase (MAPK). To date, the role of MAPK in control of meiosis is thought to be restricted to maintaining metaphase II arrest through stabilizing Cdk1 activity. In this paper, we find that MAPK and Cdk1 play compensatory roles to suppress the anaphase-promoting complex/cyclosome (APC/C) activity early in prometaphase, thereby allowing accumulation of APC/C substrates essential for meiosis I. Furthermore, inhibition of MAPK around the onset of APC/C activity at the transition from meiosis I to meiosis II led to accelerated completion of meiosis I and an increase in aneuploidy at metaphase II. These effects appear to be mediated via a Cdk1/MAPK-dependent stabilization of the spindle assembly checkpoint, which when inhibited leads to increased APC/C activity. These findings demonstrate new roles for MAPK in the regulation of meiosis in mammalian oocytes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.