ReviewCurrent opinion in neurobiology2014
Spatiotemporal specificity in cholinergic control of neocortical function.
Review in Current opinion in neurobiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
69 citing papers in PubMed.
- Quantitative anatomy and biophysical modeling of ascending neuromodulatory systems in the developing rat neocortex.PLoS computational biology · 2026Article
- Spatiotemporally dynamic noradrenergic regulation of cortical networks.bioRxiv : the preprint server for biology · 2026Article
- Dynamic cholinergic signaling differentially desynchronizes cortical microcircuits dependent on modulation rate and network connectivity.PLoS computational biology · 2026Article
- A brain-wide, trial- and time-dependent deterministic drive synergizes with within-trial noise to time self-initiated actions.bioRxiv : the preprint server for biology · 2026Article
- Transcriptional and functional profiles of muscarinic receptor-expressing neurons in primate lateral prefrontal and anterior cingulate cortices.Communications biology · 2026Article
- Cell-type-specific cholinergic control of granular retrosplenial cortex with implications for angular velocity coding across brain states.Progress in neurobiology · 2025Article
- Article
- An enhancer-AAV toolbox to target and manipulate distinct interneuron subtypes.bioRxiv : the preprint server for biology · 2025Article
- Differential behavioral engagement of inhibitory interneuron subtypes in the zebra finch brain.Neuron · 2025Article
- Slow and fast cortical cholinergic arousal is reduced in a mouse model of focal seizures with impaired consciousness.Cell reports · 2024Article
- Multimodal gradients of basal forebrain connectivity across the neocortex.Nature communications · 2024Article
- M2 receptors are required for spatiotemporal sequence learning in mouse primary visual cortex.Journal of neurophysiology · 2024Article
- Distributed and dynamical communication: a mechanism for flexible cortico-cortical interactions and its functional roles in visual attention.Communications biology · 2024Article
- Article
- Maternal choline supplementation protects against age-associated cholinergic and GABAergic basal forebrain neuron degeneration in the Ts65Dn mouse model of Down syndrome and Alzheimer's disease.Neurobiology of disease · 2023Article
- Adaptive control of synaptic plasticity integrates micro- and macroscopic network function.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Review
- Spatiotemporally heterogeneous coordination of cholinergic and neocortical activity.Nature neuroscience · 2022Article
- Genetically tagging cholinergic diversity.Neuron · 2022Article
- Article
- Cell-Type Specific Neuromodulation of Excitatory and Inhibitory NeuronsFrontiers in neural circuits · 2022Article
9 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Cholinergic actions are critical for normal cortical cognitive functions. The release of acetylcholine (ACh) in neocortex and the impact of this neuromodulator on cortical computations exhibit remarkable spatiotemporal precision, as required for the regulation of behavioral processes underlying attention and learning. We discuss how the organization of the cholinergic projections to the cortex and their release properties might contribute to this specificity. We also review recent studies suggesting that the modulatory influences of ACh on the properties of cortical neurons can have the necessary temporal dynamic range, emphasizing evidence of powerful interneuron subtype-specific effects. We discuss areas that require further investigation and point to technical advances in molecular and genetic manipulations that promise to make headway in understanding the neural bases of cholinergic modulation of cortical cognitive operations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.