ArticlePsychoneuroendocrinology2014
Plasma IL-12 levels are suppressed in vivo by stress and surgery through endogenous release of glucocorticoids and prostaglandins but not catecholamines or opioids.
Article in Psychoneuroendocrinology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 24 citations in OpenAlex.
- Fast and slow gene expression changes in blood following acute social stress.Brain, behavior, & immunity - health · 2026Article
- Type of anesthesia for cancer resection surgery: No differential impact on cancer recurrence in mouse models of breast cancer.PloS one · 2023Article
- Combination of early Interleukin-6 and -18 levels predicts postoperative nosocomial infection.Frontiers in endocrinology · 2022Article
- Stress and cancer: mechanisms, significance and future directions.Nature reviews. Cancer · 2021Review
- Harnessing cancer immunotherapy during the unexploited immediate perioperative period.Nature reviews. Clinical oncology · 2020Review
- Chronic stress-induced immune dysregulation in cancer: implications for initiation, progression, metastasis, and treatment.American journal of cancer research · 2020Review
- The impact of psychosocial stress and stress management on immune responses in patients with cancer.Cancer · 2019Review
- Cytokine, chemokine and BDNF levels in medication-free pediatric patients with obsessive-compulsive disorder.European child & adolescent psychiatry · 2018Article
- Antidepressant Effect ofBioMed research international · 2018Article
- Serum amyloid A: an ozone-induced circulating factor with potentially important functions in the lung-brain axis.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2017Article
- Stress impairs the efficacy of immune stimulation by CpG-C: Potential neuroendocrine mediating mechanisms and significance to tumor metastasis and the perioperative period.Brain, behavior, and immunity · 2016Article
- Perioperative treatment with the new synthetic TLR-4 agonist GLA-SE reduces cancer metastasis without adverse effects.International journal of cancer · 2016Article
- Macrophage depletion reduces postsurgical tumor recurrence and metastatic growth in a spontaneous murine model of melanoma.Oncotarget · 2015Article
- The misleading nature of in vitro and ex vivo findings in studying the impact of stress hormones on NK cell cytotoxicity.Brain, behavior, and immunity · 2015Article
- Salivary markers of inflammation in response to acute stress.Brain, behavior, and immunity · 2015Review
- A nervous tumor microenvironment: the impact of adrenergic stress on cancer cells, immunosuppression, and immunotherapeutic response.Cancer immunology, immunotherapy : CII · 2014Review
- Chronic stress causes neuroendocrine-immune disturbances without affecting renal vitamin D metabolism in rats.Journal of endocrinological investigation · 2014Article
- PGE2 suppresses NK activity in vivo directly and through adrenal hormones: effects that cannot be reflected by ex vivo assessment of NK cytotoxicity.Brain, behavior, and immunity · 2013Article
- Biobehavioral Pathways and Cancer Progression: Insights for Improving Well-Being and Cancer Outcomes.Integrative cancer therapiesReview
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Authors and funding
8 authors at 2 institutions in 3 countries.
Funding
Abstract
IL-12 is a prominent Th1 differentiator and leukocyte activator. Ample studies showed suppression of IL-12 production by numerous stress factors, including prostaglandins, catecholamines, glucocorticoids, and opioids, but did so in vitro and in the context of artificial leukocyte activation, not simulating the in vivo setting. In a recent study we reported in vivo suppression of plasma IL-12 levels by behavioral stress and surgery. The current study aims to elucidate neuroendocrine mechanisms underlying this phenomenon in naïve F344 rats. To this end, both adrenalectomy and administration of specific antagonists were used, targeting the aforementioned stress factors. The results indicated that corticosterone and prostaglandins are prominent mediators of the IL-12-suppressing effects of stress and surgery, apparently through directly suppressing leukocyte IL-12 production. Following surgery, endogenous prostaglandins exerted their effects mainly through elevating corticosterone levels. Importantly, stress-induced release of epinephrine or opioids had no impact on plasma IL-12 levels, while pharmacological administration of epinephrine reduced plasma IL-12 levels by elevating corticosterone levels. Last, a whole blood in vitro study indicated that prostaglandins and corticosterone, but not epinephrine, suppressed IL-12 production in non-stimulated leukocytes, and only corticosterone did so in the context of CpG-C-induced IL-12 production. Overall, the findings reiterate the notion that results from in vitro or pharmacological in vivo studies cannot indicate the effects of endogenously released stress hormones under stress/surgery conditions. Herein, corticosterone and prostaglandins, but not catecholamines or opioids, were key mediators of the suppressive effect of stress and surgery on in vivo plasma IL-12 levels in otherwise naïve animals.
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