ArticleFertility and sterility2014
A novel "delayed start" protocol with gonadotropin-releasing hormone antagonist improves outcomes in poor responders.
Article in Fertility and sterility, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05521828 (Luteal Phase Ovarian Stimulation With Follitropin Delta and Dydrogesterone), which is not on this map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Luteal Phase Ovarian Stimulation With Follitropin Delta and Dydrogesterone: a Randomized Cross Over Pilot Trial
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Efficacy of the delayed start antagonist protocol for controlled ovarian stimulation in Bologna poor ovarian responders: a systematic review and meta-analysis.Archives of gynecology and obstetrics · 2021Pooled it
- Does the "delayed start" protocol with gonadotropin-releasing hormone antagonist improve the pregnancy outcome in Bologna poor responders? a randomized clinical trial.Reproductive biology and endocrinology : RB&E · 2018Trial
- Interpretable machine learning model for predicting MII oocyte retrieved following controlled ovarian stimulation: a retrospective cohort study of 24,976 IVF/ICSI cycles.Journal of assisted reproduction and genetics · 2025Article
- Impact of Luteinizing Hormone on IVF/ICSI Assisted Reproduction on the Initiation Day of Gonadotropin-releasing Hormone Antagonist Protocol.Endocrine, metabolic & immune disorders drug targets · 2025Article
- Stem-Cell-Derived Extracellular Vesicles: Unlocking New Possibilities for Treating Diminished Ovarian Reserve and Premature Ovarian Insufficiency.Life (Basel, Switzerland) · 2023Review
- Ovarian stimulation protocols for poor ovarian responders: a network meta-analysis of randomized controlled trials.Archives of gynecology and obstetrics · 2023Article
- Original delayed-start ovarian stimulation protocol with a gonadotropin-releasing hormone antagonist, medroxyprogesterone acetate, and high-dose gonadotropin for poor responders and patients with poor-quality embryos.Frontiers in endocrinology · 2023Article
- Understanding the Ovarian Interrelationship with Low Antral Follicle Counts (AFC) in the In VivoBiology · 2022Article
- Growth hormone supplementation during ovarian stimulation improves oocyte and embryo outcomes in IVF/PGT-A cycles of women who are not poor responders.Journal of assisted reproduction and genetics · 2021Article
- Controlled ovarian hyperstimulation for fertility preservation in women with breast cancer: Practical issues.Clinical and experimental reproductive medicine · 2021Article
- A flexible short protocol in women with poor ovarian response over 40 years old.Journal of ovarian research · 2021Article
- Enhancement of outcome in women with poor ovarian responses.Journal of the Chinese Medical Association : JCMA · 2020Article
- Delayed Start Protocol with Gonadotropin-releasing Hormone Antagonist in Poor Responders Undergoing In Vitro Fertilization: A Randomized, Double-blinded, Clinical Trial.Oman medical journal · 2018Article
- Fertility preservation: ovarian response to freeze oocytes is not affected by different malignant diseases-an analysis of 992 stimulations.Journal of assisted reproduction and genetics · 2018Article
- Pregnancy outcome in delayed start antagonist versus microdose flare GnRH agonist protocol in poor responders undergoing IVF/ICSI: An RCT.International journal of reproductive biomedicine · 2018Article
- Long-term outcomes in cancer patients who did or did not pursue fertility preservation.Fertility and sterility · 2018Article
- Efficacy of luteal estrogen administration and an early follicular Gonadotropin-releasing hormone antagonist priming protocol in poor responders undergoingObstetrics & gynecology science · 2018Article
- Pregnancy outcome of "delayed start" GnRH antagonist protocol versus GnRH antagonist protocol in poor responders: A clinical trial study.International journal of reproductive biomedicine · 2017Article
- Clinical analyses of successful and previously failed intracytoplasmic sperm injection cycle parameters in patients with poor ovarian reserve.Turkish journal of obstetrics and gynecology · 2017Article
- The Ideal Stimulation Protocol: Is There One?Journal of obstetrics and gynaecology of India · 2015Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
objectiveTo investigate whether delaying the start of ovarian stimulation with GnRH antagonist improves ovarian response in poor responders.
designRetrospective study.
settingAcademic medical center. PATIENT(S): Thirty patients, who responded poorly and did not get pregnant with conventional estrogen priming antagonist IVF protocol. INTERVENTION(S): Delayed-start antagonist protocol (estrogen priming followed by early follicular-phase GnRH antagonist treatment for 7 days before ovarian stimulation). MAIN OUTCOME MEASURE(S): Number of dominant follicles and mature oocytes retrieved, mature oocyte yield, and fertilization rate. RESULT(S): The number of patients who met the criteria to proceed to oocyte retrieval was significantly higher in the delayed-start protocol [21/30 (70%)] compared with the previous conventional estrogen priming antagonist cycle [11/30 (36.7%)]. The number of dominant follicles was significantly higher in the delayed-start (4.2 ± 2.7) compared with conventional (2.4 ± 1.3) protocol. In patients who had oocyte retrieval after both protocols (n = 9), the delayed start resulted in shorter ovarian stimulation (9.4 ± 1.4 days vs. 11.1 ± 2.0 days), higher number of mature oocytes retrieved (4.9 ± 2.0 vs. 2.2 ± 1.1), and a trend toward increased fertilization rates with intracytoplasmic sperm injection (ICSI; 86 ± 17% vs. 69 ± 21%) compared with conventional protocol. After delayed start, the average number of embryos transferred was 2.8 ± 1.4 with implantation rate of 9.8% and clinical pregnancy rate of 23.8%. CONCLUSION(S): The delayed-start protocol improves ovarian response in poor responders by promoting and synchronizing follicle development without impairing oocyte developmental competence.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.