Evidence map›Paper›PMID 24636395›Full record

Trial reportFertility and sterility2014

High-dose vitamin D supplementation and measures of insulin sensitivity in polycystic ovary syndrome: a randomized, controlled pilot trial.

Nazia Raja-Khan, Julie Shah, Christy M Stetter, Mary E J Lott, Allen R Kunselman, William C Dodson, Richard S Legro

2 registry-linked trialsOpen access · bronzeAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Fertility and sterility, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 39 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed, 10 pooled it
9.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00907153 phase1 / phase2completednot on this map

Vitamin D Supplementation in Polycystic Ovary Syndrome: a Randomized Controlled Trial.

TypeinterventionalSponsorMilton S. Hershey Medical CenterRan2009 to 2014Enrolled36ConditionsPolycystic Ovary SyndromeArmsVitamin D, Placebo
NCT02803476 unknown statusnot on this mapstarted 2016, after this paper: background citation

Is There An Association Between Vitamin D Levels And Insulin Resistance In Polycystic Ovary Syndrome?

TypeobservationalSponsorAin Shams Maternity HospitalRan2016 to 2016Enrolled166ConditionsPolycystic Ovary Syndrome, Insulin Resistance, Vitamin D Deficiency
3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 10 syntheses or guidelines pooled it, 79 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Nazia Raja-KhanDivision of Endocrinology, Diabetes, and Metabolism, Pennsylvania State University College of Medicine, Hershey, Pennsylvania. Electronic address: nrajakhan@psu.edu.
Julie ShahDivision of Endocrinology, Diabetes, and Metabolism, Pennsylvania State University College of Medicine, Hershey, Pennsylvania.
Christy M StetterDepartment of Public Health Sciences, Pennsylvania State University College of Medicine, Hershey, Pennsylvania.
Mary E J LottHeart and Vascular Institute, Pennsylvania State University College of Medicine, Hershey, Pennsylvania.
Allen R KunselmanDepartment of Public Health Sciences, Pennsylvania State University College of Medicine, Hershey, Pennsylvania.
William C DodsonDepartment of Obstetrics and Gynecology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania.
Richard S LegroDepartment of Obstetrics and Gynecology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania.
Penn State Milton S. Hershey Medical Center · USPennsylvania State University · US

Funding

Penn State Clinical and Translational Science InstituteUL1TR000127 · NCATS · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI SINOWAY, LAWRENCE I · 2012 to 2015
$17.1M
NCATS NIH HHS UL1 TR000127NCATS NIH HHS UL1TR000127
6 · The paper itself

Abstract

objectiveTo determine the effects of high-dose vitamin D on insulin sensitivity in polycystic ovary syndrome (PCOS).

designRandomized, placebo-controlled trial.

settingAcademic medical center. PATIENT(S): Twenty-eight women with PCOS. INTERVENTION(S): Vitamin D3, 12,000 IU, or placebo daily for 12 weeks. MAIN OUTCOME MEASURE(S): The primary outcome was quantitative insulin sensitivity check index. Secondary outcomes included glucose and insulin levels during a 75-g oral glucose tolerance test and blood pressure. RESULT(S): Twenty-two women completed the study. Compared with placebo, vitamin D significantly increased 25-hydroxyvitamin D (mean [95% confidence interval] in vitamin D group 20.1 [15.7 to 24.5] ng/mL at baseline and 65.7 [52.3 to 79.2] ng/mL at 12 weeks; placebo 22.5 [18.1 to 26.8] ng/mL at baseline and 23.8 [10.4 to 37.2] ng/mL at 12 weeks). There were no significant differences in quantitative insulin sensitivity check index and other measures of insulin sensitivity; however, we observed trends toward lower 2-hour insulin and lower 2-hour glucose. We also observed a protective effect of vitamin D on blood pressure. CONCLUSION(S): In women with PCOS, insulin sensitivity was unchanged with high-dose vitamin D, but there was a trend toward decreased 2-hour insulin and a protective effect on blood pressure. CLINICAL TRIAL REGISTRATION NUMBER: NCT00907153.

Indexed as

Dietary SupplementsInsulin ResistanceAcademic Medical CentersAdolescentAdultBiomarkersBlood GlucoseBlood PressureCholecalciferolDouble-Blind MethodFemaleGlucose Tolerance TestHumansInsulinMiddle AgedPennsylvaniaBiomarkersBlood GlucoseCholecalciferolInsulinVitaminsblood pressureinsulin resistancePolycystic ovary syndromevitamin D

Identifiers

PMID24636395
PMCPMC4537163
OpenAlexW1972425341

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.