ArticleJournal of the International Society of Sports Nutrition2014
Antioxidant and anti-nociceptive effects of Phyllanthus amarus on improving exercise recovery in sedentary men: a randomized crossover (double-blind) design.
Article in Journal of the International Society of Sports Nutrition, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.
- Antioxidants for preventing and reducing muscle soreness after exercise.The Cochrane database of systematic reviews · 2017Pooled it
- Diabetes mellitus in ECOWAS: an overview of the safety and efficacy of medicinal plants used in traditional medicine practices.Tropical medicine and health · 2026Review
- The reliability of functional and systemic markers of muscle damage in response to a flywheel squat protocol.European journal of applied physiology · 2025Article
- Harmony in Motion: Unraveling the Nexus of Sports, Plant-Based Nutrition, and Antioxidants for Peak Performance.Antioxidants (Basel, Switzerland) · 2024Review
- An insight into the potent medicinal plantThe Nucleus : an international journal of cytology and allied topics · 2022Review
- Sciatic Nerve Structural and Functional Recovery with Extract of Phyllanthus amarus and Esculetin in STZ-Induced Hyperglycemic Rats.Annals of neurosciences · 2019Article
- Nutritional and Supplementation Strategies to Prevent and Attenuate Exercise-Induced Muscle Damage: a Brief Review.Sports medicine - open · 2019Review
- The inhibitory activity of herbal medicines on the keys enzymes and steps related to carbohydrate and lipid digestion.BMC complementary and alternative medicine · 2016Article
- Influence of preliminary exercise training on muscle damage indices in rats after one bout of prolonged treadmill exercise.Journal of physical therapy science · 2016Article
- Antioxidant effect of Phyllanthus amarus after moderate-intensity exercise in sedentary males: a randomized crossover (double-blind) study.Journal of physical therapy science · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPhyllanthus amarus (PA) is a herbal plant containing antioxidant compounds that scavenge free radicals. The reduced oxidative stress may decrease muscle damage leading to early recovery from muscle soreness. This study aimed to evaluate the effects of PA powder on oxidative stress, muscle damage, leukocyte counts, inflammation, and muscle soreness after a single bout of high-intensity exercise.
methodsTwelve men participated in two 3-day phases separated by a 1-week washout in a randomized double-blinded, crossover design. On day 1, randomly divided participants ingested two capsules of either PA (PA group) or placebo (PLA group) 20 min before a single bout of cycling at high intensity for 20 min followed by four capsules (two capsules after lunch and dinner), and six capsules/day for the next 2 days. Blood samples were collected before, immediately after, and 24 and 48 h after the exercise. Pain threshold was measured at the mid-thigh on both legs.
resultsMalondialdehyde concentration in the PA group was lower than that in the PLA group (p < 0.05) 48 h after high-intensity exercise. Vitamin C concentration was greater in the PA than in the PLA group (p < 0.05) immediately after high-intensity exercise. Pain threshold in both legs in the PA group was higher than in the PLA group 24 and 48 h after high-intensity exercise. There were no significant differences in creatine kinase, leukocyte counts or inflammation between groups.
conclusionAcute PA supplementation reduced oxidative stress and muscle soreness induced by high-intensity exercise.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.