ArticleThe Journal of allergy and clinical immunology2014
Atopic phenotypes identified with latent class analyses at age 2 years.
Article in The Journal of allergy and clinical immunology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
52 citing papers in PubMed.
- Allergic sensitization does not differ between childhood- and adolescent-onset asthma in women.The Journal of allergy and clinical immunology · 2020Trial
- Phenotypes of Recurrent Wheezing in Preschool Children: Identification by Latent Class Analysis and Utility in Prediction of Future Exacerbation.The journal of allergy and clinical immunology. In practice · 2019Trial
- Delayed gut microbiota development in high-risk for asthma infants is temporarily modifiable by Lactobacillus supplementation.Nature communications · 2018Trial
- Early-Life Allergen Sensitization Phenotypes and Exploratory Machine-Learning Interpretation of School-Age Asthma Risk.Journal of asthma and allergy · 2026Article
- Clustering lung function and symptom profiles for asthma risk stratification.Scientific reports · 2025Article
- Asthma Phenotypes and Biomarkers.Respiratory care · 2025Review
- Artificial intelligence in pediatric allergy research.European journal of pediatrics · 2024Review
- The new biologic drugs: Which children with asthma should get what?Pediatric pulmonology · 2024Review
- Bridging Differences in Cohort Analyses of the Relationship between Secondhand Smoke Exposure during Pregnancy and Birth Weight: The Transportability Framework in the ECHO Program.Environmental health perspectives · 2024Article
- Adolescent and young adult allergic asthma treatment challenges.BMJ case reports · 2022Article
- Financial burden and impact of atopic dermatitis out-of-pocket healthcare expenses among black individuals in the United States.Archives of dermatological research · 2022Article
- Allergic sensitization trajectories to age 8 years in the Singapore GUSTO cohort.The World Allergy Organization journal · 2022Article
- Evaluating the Longitudinal Course of Atopic Dermatitis: Implications for Clinical Practice.American journal of clinical dermatology · 2022Review
- Time-Specific Factors Influencing the Development of Asthma in Children.Biomedicines · 2022Review
- Deprivation of Dietary Fiber Enhances Susceptibility of Piglets to Lung Immune Stress.Frontiers in nutrition · 2022Article
- Genetics of Asthma and Allergic Diseases.Handbook of experimental pharmacology · 2022Article
- Human Microbiome in Children, at the Crossroad of Social Determinants of Health and Personalized Medicine.Children (Basel, Switzerland) · 2021Article
- Endotype of allergic asthma with airway obstruction in urban children.The Journal of allergy and clinical immunology · 2021Article
- Increased risk of asthma at age 10 years for children sensitized to multiple allergens.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2021Article
- Risk, Mechanisms and Implications of Asthma-Associated Infectious and Inflammatory Multimorbidities (AIMs) among Individuals With Asthma: a Systematic Review and a Case Study.Allergy, asthma & immunology research · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
backgroundAtopic sensitization (ie, atopy) is the most commonly reported risk factor for asthma. Recent studies have begun to suggest that atopy, as conventionally defined, might be an umbrella term that obfuscates more specific allergic disease types.
objectiveWe sought to determine whether distinct and meaningful atopic phenotypes exist within a racially diverse birth cohort using 10 allergen-specific serum IgE (sIgE) measurements from children aged 2 years.
methodsUsing the Wayne County Health, Environment, Allergy and Asthma Longitudinal Study (WHEALS) birth cohort (62% black), we analyzed sIgE data on 10 allergens (Dermatophagoides farinae, dog, cat, timothy grass, ragweed, Alternaria alternata, egg, peanut, milk, and German cockroach) obtained from 594 children at age 2 years. Conventional atopy was defined as at least 1 sIgE level of 0.35 IU/mL or greater.
resultsA 4-class solution (latent class model) was the best fit. Class types were labeled "low to no sensitization" (76.9% of sample), "highly sensitized" (2.7%), "milk and egg dominated" (15.3%), and "peanut and inhalant(s)" (5.1%). Almost one third (32.2%) of the low to no sensitization group met the criteria for conventional atopy. The highly sensitized group was significantly associated with a doctor's diagnosis of asthma after age 4 years (odds ratio [OR], 5.3; 95% CI, 1.6-17.4), whereas the milk and egg dominated and peanut and inhalant(s) groups were not (ORs of 1.6 [95% CI, 0.8-3.0] and 1.8 [95% CI, 0.6-4.9], respectively). Children of black race were more likely to be in the 3 multisensitized groups (P = .04).
conclusionClassification by sIgE patterns defined groups whose membership is more strongly associated with atopic dermatitis, wheeze, and asthma compared with conventional atopy.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.