Evidence map›Paper›PMID 24635665›Full record

ReviewJournal of the American Geriatrics Society2014

Management of neuropsychiatric symptoms of dementia in clinical settings: recommendations from a multidisciplinary expert panel.

Helen C Kales, Laura N Gitlin, Constantine G Lyketsos, Detroit Expert Panel on Assessment and Management of Neuropsychiatric Symptoms of Dementia

Registry-linked trialOpen access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of the American Geriatrics Society, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05827276 (Effects of the Life Story Questionnaire on Physical Therapy Participation in Patients With Dementia), which is not on this map. Cited by 220 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
220citing papers in PubMed, 11 pooled it
28.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05827276 naunknown statusnot on this mapstarted 2023, after this paper: background citation

Effects of the Life Story Questionnaire on Physical Therapy Participation in Patients With Dementia: A Randomized Control Trial

TypeinterventionalSponsorTexas Tech University Health Sciences CenterRan2023 to 2024Enrolled60ConditionsDementia AlzheimersArmsLife story questionnaire
3 · Its place in the literature

Who cites it

220 citing papers in PubMed, 11 syntheses or guidelines pooled it, 571 citations in OpenAlex.

  1. Efficacy and safety of brexpiprazole for the treatment of agitation in Alzheimer's disease: a meta-analysis of randomized controlled trials.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024
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  7. Driving and Alzheimer's dementia or mild cognitive impairment: a systematic review of the existing guidelines emphasizing on the neurologist's role.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2021
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  12. Considerations for Use of the Cornell Scale for Depression in Dementia Among Assisted Living Residents: Factor Analysis Results.Journal of applied gerontology : the official journal of the Southern Gerontological Society · 2025
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  20. Teaching Caregivers of Persons with Dementia to Address Pain.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2017
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160 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Helen C KalesSection of Geriatric Psychiatry, Department of Psychiatry, University of Michigan, Ann Arbor, Michigan; Department of Veterans Affairs, VA Center for Clinical Management Research, Ann Arbor, Michigan; Geriatric Research, Education and Clinical Center, VA Ann Arbor Healthcare System, Ann Arbor, Michigan.
Laura N Gitlin
Constantine G Lyketsos
Detroit Expert Panel on Assessment and Management of Neuropsychiatric Symptoms of Dementia
Johns Hopkins Bayview Medical Center · USJohns Hopkins Medicine · USVA Center for Clinical Management Research · US

Funding

Institute for Clinical and Translational ResearchUL1TR001079 · NCATS · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2013 to 2017
$60.1M
'T V ASSESSMENT - MEMORY DISORDERED PATIENTS'P50AG005146 · NIA · JOHNS HOPKINS UNIVERSITY · PI HUGANIR, RICHARD L · 1985 to 2019
$37.6M
An Innovative Caregiver Tool to Assess and Manage Behavioral Symptoms of DementiaR01NR014200 · NINR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI GITLIN, LAURA N., KALES, HELEN C · 2012 to 2015
$1.6M
NCATS NIH HHS UL1 TR001079NIA NIH HHS P50 AG005146NIA NIH HHS P50AG005146NINR NIH HHS R01 NR014200NINR NIH HHS R01NR014200
6 · The paper itself

Abstract

Noncognitive neuropsychiatric symptoms (NPS) of dementia (aggression, agitation, depression, anxiety, delusions, hallucinations, apathy, disinhibition) affect individuals with dementia nearly universally across dementia stages and etiologies. NPS are associated with poor outcomes for individuals with dementia and caregivers, including excess morbidity and mortality, greater healthcare use, and earlier nursing home placement, as well as caregiver stress, depression, and difficulty with employment. Although the Food and Drug Administration has not approved pharmacotherapy for NPS, psychotropic medications are frequently used to manage these symptoms, but in the few cases of proven pharmacological efficacy, significant risk of adverse effects may offset benefits. There is evidence of efficacy and limited potential for adverse effects of nonpharmacological treatments, typically considered first line, but their uptake as preferred treatments remains inadequate in real-world clinical settings. Thus, the field currently finds itself in a predicament in terms of management of these difficult symptoms. It was in this context that the University of Michigan Program for Positive Aging, working in collaboration with the Johns Hopkins Alzheimer's Disease Research Center and Center for Innovative Care in Aging sponsored and convened a multidisciplinary expert panel in Detroit, Michigan, in fall 2011 with three objectives: to define critical elements of care for NPS in dementia; to construct an approach describing the sequential and iterative steps of managing NPS in real-world clinical settings that can be used as a basis for integrating nonpharmacological and pharmacological approaches; and to discuss how the approach generated could be implemented in research and clinical care.

Indexed as

Disease ManagementPractice Guidelines as TopicBehavior TherapyCrisis InterventionDementiaHumansNeuropsychological TestsSeverity of Illness Indexbehaviorbehavioral managementnon-pharmacological management

Identifiers

PMID24635665
PMCPMC4146407
OpenAlexW1976117775

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.