ArticleThe Plant journal : for cell and molecular biology2014
The Arabidopsis thaliana tandem zinc finger 1 (AtTZF1) protein in RNA binding and decay.
Article in The Plant journal : for cell and molecular biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 57 citations in OpenAlex.
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- Exploiting plant immune "switches" for resistance engineering.Stress biology · 2026Review
- The non-tandem CCCH zinc finger protein AtC3H26 modulates salt stress response and phosphate starvation response through its ribonuclease activity in Arabidopsis.BMC plant biology · 2025Article
- Modulation of stress granule dynamics by phosphorylation and ubiquitination in plants.iScience · 2024Article
- Overexpression of stress granule protein TZF1 enhances salt stress tolerance by targetingFrontiers in plant science · 2024Article
- A LlMYB305-LlC3H18-LlWRKY33 module regulates thermotolerance in lily.Molecular horticulture · 2023Article
- Review
- Genomic Identification of CCCH-Type Zinc Finger Protein Genes Reveals the Role ofInternational journal of molecular sciences · 2023Article
- Hormone Regulation of CCCH Zinc Finger Proteins in Plants.International journal of molecular sciences · 2022Review
- STRONG STAYGREEN inhibits DNA binding of PvNAP transcription factors during leaf senescence in switchgrass.Plant physiology · 2022Article
- RNA Binding Protein OsTZF7 Traffics Between the Nucleus and Processing Bodies/Stress Granules and Positively Regulates Drought Stress in Rice.Frontiers in plant science · 2022Article
- Transcriptome profiling of Arabidopsis thaliana roots in response to allelopathic effects of Conyza canadensis.Ecotoxicology (London, England) · 2022Article
- The intertwining of Zn-finger motifs and abiotic stress tolerance in plants: Current status and future prospects.Frontiers in plant science · 2022Review
- Reprogramming of RNA silencing triggered by cucumber mosaic virus infection in Arabidopsis.Genome biology · 2021Article
- Systematic analysis of CCCH zinc finger family in Brassica napus showed that BnRR-TZFs are involved in stress resistance.BMC plant biology · 2021Article
- Noncanonical mono(ADP-ribosyl)ation of zinc finger SZF proteins counteracts ubiquitination for protein homeostasis in plant immunity.Molecular cell · 2021Article
- The Roles of CCCH Zinc-Finger Proteins in Plant Abiotic Stress Tolerance.International journal of molecular sciences · 2021Review
- Sugar Signaling and Post-transcriptional Regulation in Plants: An Overlooked or an Emerging Topic?Frontiers in plant science · 2020Review
- PRR5, 7 and 9 positively modulate TOR signaling-mediated root cell proliferation by repressing TANDEM ZINC FINGER 1 in Arabidopsis.Nucleic acids research · 2019Article
- The zinc finger protein DCM1 is required for male meiotic cytokinesis by preserving callose in rice.PLoS genetics · 2018Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
The Arabidopsis thaliana tandem zinc finger 1 (AtTZF1) protein is characterized by two tandem-arrayed CCCH-type zinc fingers. We have previously found that AtTZF1 affects hormone-mediated growth, stress and gene expression responses. While much has been learned at the genetic and physiological level, the molecular mechanisms underlying the effects of AtTZF1 on gene expression remain obscure. A human TZF protein, hTTP, is known to bind and trigger the degradation of mRNAs containing AU-rich elements (AREs) at the 3' untranslated regions. However, while the TZF motif of hTTP is characterized by C(X8)C(X5)C(X3)H-(X18)-C(X8)C(X5)C(X3)H, AtTZF1 contains an atypical motif of C(X7)C(X5)C(X3)H-(X16)-C(X5)C(X4)C(X3)H. Moreover, the TZF motif of AtTZF1 is preceded by an arginine-rich (RR) region that is unique to plants. Using fluorescence anisotropy and electrophoretic mobility shift binding assays, we have demonstrated that AtTZF1 binds to RNA molecules with specificity and the interaction is dependent on the presence of zinc. Compared with hTTP, in which TZF is solely responsible for RNA binding, both TZF and RR regions of AtTZF1 are required to achieve high-affinity RNA binding. Moreover, zinc finger integrity is vital for RNA binding. Using a plant protoplast transient expression analysis we have further revealed that AtTZF1 can trigger the decay of ARE-containing mRNAs in vivo. Taken together, our results support the notion that AtTZF1 is involved in RNA turnover.
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