Evidence map›Paper›PMID 24634837›Full record

ArticleRedox biology2014

Curcumin may impair iron status when fed to mice for six months.

Dawn Chin, Patricia Huebbe, Jan Frank, Gerald Rimbach, Kathrin Pallauf

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Redox biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed, 1 pooled it
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 1 synthesis or guideline pooled it, 80 citations in OpenAlex.

  1. Pooled it
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  7. A Tolerance Study of Turmeric Extract in Healthy Adult Cats.Animals : an open access journal from MDPI · 2026
    Article
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  12. Article
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  15. Article
  16. Influence of CurQfenFrontiers in dementia · 2023
    Article
  17. Review
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  19. Iron Metabolism in Aging and Age-Related Diseases.International journal of molecular sciences · 2022
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Dawn ChinInstitute of Human Nutrition and Food Science, Christian-Albrechts-University Kiel, Hermann-Rodewald-Strasse 6-8, D-24118 Kiel, Germany.
Patricia HuebbeInstitute of Human Nutrition and Food Science, Christian-Albrechts-University Kiel, Hermann-Rodewald-Strasse 6-8, D-24118 Kiel, Germany.
Jan FrankInstitute of Biological Chemistry and Nutrition, University of Hohenheim, Garbenstrasse 28, D-70599 Stuttgart, Germany.
Gerald RimbachInstitute of Human Nutrition and Food Science, Christian-Albrechts-University Kiel, Hermann-Rodewald-Strasse 6-8, D-24118 Kiel, Germany.
Kathrin PallaufInstitute of Human Nutrition and Food Science, Christian-Albrechts-University Kiel, Hermann-Rodewald-Strasse 6-8, D-24118 Kiel, Germany.
Christian-Albrechts-Universität zu Kiel · DEUniversity of Hohenheim · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Curcumin has been shown to have many potentially health beneficial properties in vitro and in animal models with clinical studies on the toxicity of curcumin reporting no major side effects. However, curcumin may chelate dietary trace elements and could thus potentially exert adverse effects. Here, we investigated the effects of a 6 month dietary supplementation with 0.2% curcumin on iron, zinc, and copper status in C57BL/6J mice. Compared to non-supplemented control mice, we observed a significant reduction in iron, but not zinc and copper stores, in the liver and the spleen, as well as strongly suppressed liver hepcidin and ferritin expression in the curcumin-supplemented mice. The expression of the iron-importing transport proteins divalent metal transporter 1 and transferrin receptor 1 was induced, while hepatic and splenic inflammatory markers were not affected in the curcumin-fed mice. The mRNA expression of other putative target genes of curcumin, including the nuclear factor (erythroid-derived 2)-like 2 and haem oxygenase 1 did not differ between the groups. Most of the published animal trials with curcumin-feeding have not reported adverse effects on iron status or the spleen. However, it is possible that long-term curcumin supplementation and a Western-type diet may aggravate iron deficiency. Therefore, our findings show that further studies are needed to evaluate the effect of curcumin supplementation on iron status.

Indexed as

AnimalsBody WeightCopperCurcuminDietary SupplementsDose-Response Relationship, DrugDrug Administration ScheduleFemaleFerritinsGene Expression RegulationHepcidinsIronLiverMiceMice, Inbred C57BLSpleenCopperCurcuminFerritinsHepcidinsIronZincCurcuminDMT1, divalent metal transporter 1Enlarged spleenFPN, ferroportinHO1, haem oxygenaseIL, interleukinIron storeLiver mineralsNQO1, NAD(P)H quinone oxidoreductaseNRF2, nuclear factor (erythroid-derived 2)-like 2qRT-PCR, quantitative real-time polymerase chain reactionSafetyTBS, tris buffered salineTfR1, transferrin receptor 1TNFα, tumour necrosis factor αToxicityγ-GCS, γ-glutamyl cysteine synthetase

Identifiers

PMID24634837
PMCPMC3953957
OpenAlexW2095258899

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.