Evidence map›Paper›PMID 24634833›Full record

ArticleNeuroImage. Clinical2014

Deficits in episodic memory retrieval reveal impaired default mode network connectivity in amnestic mild cognitive impairment.

Cameron J Dunn, Shantel L Duffy, Ian B Hickie, Jim Lagopoulos, Simon J G Lewis, Sharon L Naismith, James M Shine

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NeuroImage. Clinical, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed, 3 pooled it
4.5field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 3 syntheses or guidelines pooled it, 73 citations in OpenAlex.

  1. Pooled it
  2. A Systematic Review for Functional Neuroimaging Studies of Cognitive Reserve Across the Cognitive Aging Spectrum.Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists · 2018
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Cameron J DunnHealthy Brain Ageing Program, Clinical Research Unit, Brain & Mind Research Institute, University of Sydney, NSW, Australia.
Shantel L DuffyHealthy Brain Ageing Program, Clinical Research Unit, Brain & Mind Research Institute, University of Sydney, NSW, Australia.
Ian B HickieHealthy Brain Ageing Program, Clinical Research Unit, Brain & Mind Research Institute, University of Sydney, NSW, Australia.
Jim LagopoulosHealthy Brain Ageing Program, Clinical Research Unit, Brain & Mind Research Institute, University of Sydney, NSW, Australia.
Simon J G LewisHealthy Brain Ageing Program, Clinical Research Unit, Brain & Mind Research Institute, University of Sydney, NSW, Australia.
Sharon L NaismithHealthy Brain Ageing Program, Clinical Research Unit, Brain & Mind Research Institute, University of Sydney, NSW, Australia.
James M ShineHealthy Brain Ageing Program, Clinical Research Unit, Brain & Mind Research Institute, University of Sydney, NSW, Australia.
University of Sydney · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Amnestic mild cognitive impairment (aMCI) is believed to represent a transitional stage between normal healthy ageing and the development of dementia. In particular, aMCI patients have been shown to have higher annual transition rates to Alzheimer's Disease (AD) than individuals without cognitive impairment. Despite intensifying interest investigating the neuroanatomical basis of this transition, there remain a number of questions regarding the pathophysiological process underlying aMCI itself. A number of recent studies in aMCI have shown specific impairments in connectivity within the default mode network (DMN), which is a group of regions strongly related to episodic memory capacities. However to date, no study has investigated the integrity of the DMN between patients with aMCI and those with a non-amnestic pattern of MCI (naMCI), who have cognitive impairment, but intact memory storage systems. In this study, we contrasted the DMN connectivity in 24 aMCI and 33 naMCI patients using seed-based resting state fMRI. The two groups showed no statistical difference in their DMN intra-connectivity. However when connectivity was analysed according to performance on measures of episodic memory retrieval, the two groups were separable, with aMCI patients demonstrating impaired functional connectivity between the hippocampal formation and the posterior cingulate cortex. We provide evidence that this lack of connectivity is driven by impaired communication from the posterior cingulate hub and does not simply represent hippocampal atrophy, suggesting that posterior cingulate degeneration is the driving force behind impaired DMN connectivity in aMCI.

Indexed as

Memory, EpisodicAgedAmnesiaBrainCognitive DysfunctionConnectomeFemaleGyrus CinguliHippocampusHumansMagnetic Resonance ImagingMaleNerve NetNeural PathwaysAmnesticDefault mode networkFunctional magnetic resonance imagingMemoryMild cognitive impairmentResting state functional connectivity

Identifiers

PMID24634833
PMCPMC3952352
OpenAlexW2029954564

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.