ArticleJournal of pediatric biochemistry2014
Stable isotopes in the diagnosis and treatment of inherited hyperammonemia.
Article in Journal of pediatric biochemistry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed, 11 citations in OpenAlex.
- Characterization and treatment monitoring of ureagenesis disorders using stable isotopes.npj metabolic health and disease · 2025Article
- 1-Genetics in medicine : official journal of the American College of Medical Genetics · 2021Observational
- Primary hyperammonaemia: Current diagnostic and therapeutic strategies.Journal of mother and child · 2020Review
- Historical and contemporary stable isotope tracer approaches to studying mammalian protein metabolism.Mass spectrometry reviews · 2018Review
- Clinical experience with N-carbamylglutamate in a single-centre cohort of patients with propionic and methylmalonic aciduria.Molecular genetics and metabolism reports · 2016Article
- Concise Review: Updated Advances and Current Challenges in Cell Therapy for Inborn Liver Metabolic Defects.Stem cells translational medicine · 2016Review
- Minimal ureagenesis is necessary for survival in the murine model of hyperargininemia treated by AAV-based gene therapy.Gene therapy · 2015Article
- Metabolism of albumin after continuous venovenous hemofiltration in patients with systemic inflammatory response syndrome.BioMed research international · 2015Article
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
Abstract
Stable isotopes have greatly contributed to our understanding of nitrogen metabolism and the urea cycle. The measurement of urea flux via isotopic methods has traditionally been utilized to determine total body protein synthesis in subjects with an intact urea cycle. However, isotopic studies of nitrogen metabolism are also a useful adjunct to conventional clinical investigations in the diagnosis and management of the inherited hyperammonemias. Such studies offer a safe non-invasive method of measuring the reduction of in vivo hepatic ureagenesis, and thus may provide a more accurate measure of phenotypic severity in affected patients. In addition, isotopic methods are ideally suited to evaluate the efficacy of novel therapies to augment urea production.
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Registered trials
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