ArticleJournal of immunology (Baltimore, Md. : 1950)2014
Distinct requirements for activation of NKT and NK cells during viral infection.
Article in Journal of immunology (Baltimore, Md. : 1950), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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Who cites it
44 citing papers in PubMed, 66 citations in OpenAlex.
- A phase 1/2 clinical trial of invariant natural killer T cell therapy in moderate-severe acute respiratory distress syndrome.Nature communications · 2024Trial
- Multidimensional analyses reveal modulation of adaptive and innate immune subsets by tuberculosis vaccines.Communications biology · 2020Trial
- Salvage therapy with allogeneic invariant natural killer cells in a heavily pre-treated germ cell tumor.Oncogene · 2025Article
- Type I interferon regulation of group I ILC subsets during both homeostasis and cytomegalovirus infection.Journal of immunology (Baltimore, Md. : 1950) · 2025Article
- An activatingScience immunology · 2025Article
- Bystander CD8Frontiers in immunology · 2025Article
- The role of unconventional T cells in COVID-19.Irish journal of medical science · 2022Review
- A digital health platform for assisting the diagnosis and monitoring of COVID-19 progression: An adjuvant approach for augmenting the antiviral response and mitigating the immune-mediated target organ damage.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2021Article
- Recovery of Innate Immune Cells and Persisting Alterations in Adaptive Immunity in the Peripheral Blood of Convalescent Plasma Donors at Eight Months Post SARS-CoV-2 Infection.Microorganisms · 2021Article
- The Ugly Duckling Turned to Swan: A Change in Perception of Bystander-Activated Memory CD8 T Cells.Journal of immunology (Baltimore, Md. : 1950) · 2021Review
- Understanding the Host Innate Immune Responses against SARS-CoV-2 Infection and COVID-19 Pathogenesis.Immune network · 2021Review
- The Invariant NKT Cell Response Has Differential Signaling Requirements during Antigen-Dependent and Antigen-Independent Activation.Journal of immunology (Baltimore, Md. : 1950) · 2021Article
- Phenotypical and functional alteration of unconventional T cells in severe COVID-19 patients.The Journal of experimental medicine · 2020Article
- The Immune Modulating Properties of Mucosal-Associated Invariant T Cells.Frontiers in immunology · 2020Review
- P2Y6 signaling in alveolar macrophages prevents leukotriene-dependent type 2 allergic lung inflammation.The Journal of clinical investigation · 2019Article
- Survey of cellular immune responses to human cytomegalovirus infection in the microenvironment of the uterine-placental interface.Medical microbiology and immunology · 2019Article
- Innate and adaptive stimulation of murine diverse NKT cells result in distinct cellular responses.European journal of immunology · 2019Article
- JNK2 modulates the CD1d-dependent and -independent activation of iNKT cells.European journal of immunology · 2019Article
- CAR-armed cell therapy for gliomas.American journal of cancer research · 2019Review
- Cytomegalovirus: Shape-Shifting the Immune System.Journal of immunology (Baltimore, Md. : 1950) · 2018Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
NK cells are key regulators of innate defense against mouse CMV (MCMV). Like NK cells, NKT cells also produce high levels of IFN-γ rapidly after MCMV infection. However, whether similar mechanisms govern activation of these two cell types, as well as the significance of NKT cells for host resistance, remain unknown. In this article, we show that, although both NKT and NK cells are activated via cytokines, their particular cytokine requirements differ significantly in vitro and in vivo. IL-12 is required for NKT cell activation in vitro but is not sufficient, whereas NK cells have the capacity to be activated more promiscuously in response to individual cytokines from innate cells. In line with these results, GM-CSF-derived dendritic cells activated only NK cells upon MCMV infection, consistent with their virtual lack of IL-12 production, whereas Flt3 ligand-derived dendritic cells produced IL-12 and activated both NK and NKT cells. In vivo, NKT cell activation was abolished in IL-12(-/-) mice infected with MCMV, whereas NK cells were still activated. In turn, splenic NK cell activation was more IL-18 dependent. The differential requirements for IL-12 and IL-18 correlated with the levels of cytokine receptor expression by NK and NKT cells. Finally, mice lacking NKT cells showed reduced control of MCMV, and depleting NK cells further enhanced viral replication. Taken together, our results show that NKT and NK cells have differing requirements for cytokine-mediated activation, and both can contribute nonredundantly to MCMV defense, revealing that these two innate lymphocyte subsets function together to fine-tune antiviral responses.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.