Evidence map›Paper›PMID 24634315›Full record

ArticleStatistics in medicine2014

Binary variable multiple-model multiple imputation to address missing data mechanism uncertainty: application to a smoking cessation trial.

Juned Siddique, Ofer Harel, Catherine M Crespi, Donald Hedeker

Abstract read
In one paragraph

Article in Statistics in medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

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  4. Do Substances Used in Adolescence Predict the Persistence of Substance Use Disorders in Adulthood? A 15-Year Study of Youth After Detention.The Journal of adolescent health : official publication of the Society for Adolescent Medicine · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Juned SiddiqueDepartment of Preventive Medicine, Northwestern University, Chicago, IL, U.S.A.
Ofer Harel
Catherine M Crespi
Donald Hedeker

Funding

Women's CancersP30CA016042 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI GANG LI · 1985 to 2026
$134.5M
UCLA Clinical and Translational Science InstituteUL1TR000124 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$57.0M
STATISTICAL METHODS FOR MENTAL HEALTH PREVENTIVE TRIALSR01MH040859 · NIMH · UNIVERSITY OF SOUTH FLORIDA · PI BROWN, C. HENDRICKS · 1986 to 2014
$7.5M
Dealing with missing data in HIV prevention trialsK01MH087219 · NIMH · UNIVERSITY OF CONNECTICUT STORRS · PI HAREL, OFER · 2010 to 2014
$889k
Real Time Analysis of Diet and Activity DataK07CA154862 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI SIDDIQUE, JUNED · 2011 to 2015
$585k
Comparative Effectiveness of Medication vs. CBT in Depressed Low-Income WomenR03HS018815 · AHRQ · NORTHWESTERN UNIVERSITY AT CHICAGO · PI SIDDIQUE, JUNED · 2010 to 2011
$100k
AHRQ HHS R03 HS018815NCATS NIH HHS UL1 TR000124NCATS NIH HHS UL1TR000124NCI NIH HHS CA16042NCI NIH HHS K07 CA154862NCI NIH HHS P30 CA016042NIMH NIH HHS K01 MH087219NIMH NIH HHS R01 MH040859
6 · The paper itself

Abstract

The true missing data mechanism is never known in practice. We present a method for generating multiple imputations for binary variables, which formally incorporates missing data mechanism uncertainty. Imputations are generated from a distribution of imputation models rather than a single model, with the distribution reflecting subjective notions of missing data mechanism uncertainty. Parameter estimates and standard errors are obtained using rules for nested multiple imputation. Using simulation, we investigate the impact of missing data mechanism uncertainty on post-imputation inferences and show that incorporating this uncertainty can increase the coverage of parameter estimates. We apply our method to a longitudinal smoking cessation trial where nonignorably missing data were a concern. Our method provides a simple approach for formalizing subjective notions regarding nonresponse and can be implemented using existing imputation software.

Indexed as

Models, StatisticalUncertaintyComputer SimulationHumansSmoking Cessationbinary dataNMARnonignorablenot missing at random

Identifiers

PMID24634315
PMCPMC4082461

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.