ArticleAngewandte Chemie (International ed. in English)2014
Stimuli-responsive theragrippers for chemomechanical controlled release.
Article in Angewandte Chemie (International ed. in English), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
62 citing papers in PubMed.
- Origami and Kirigami on Nanomembranes: Design, Fabrication, and Applications.Advanced materials (Deerfield Beach, Fla.) · 2026Review
- Autonomous Hydrogel Actuators Programmed by Endogenous Biochemical Logic for Dual-Stage Morphing and Drug Release.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- Magnetic Microrobots for Drug Delivery: A Review of Fabrication Materials, Structure Designs and Drug Delivery Strategies.Molecules (Basel, Switzerland) · 2025Review
- Programmable and Reversible 3D-to-3D Shape Transformation: Hierarchical Multimodal Morphing Based on Liquid Crystal Elastomers.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Vat Photopolymerization of Smart Polymers for Biomedical Applications.ACS applied polymer materials · 2025Review
- Interparticle Crosslinked Ion-Responsive Microgels for 3D and 4D (Bio)Printing Applications.Small (Weinheim an der Bergstrasse, Germany) · 2025Article
- Technology Roadmap of Micro/Nanorobots.ACS nano · 2025Review
- Wearable and Flexible Sensor Devices: Recent Advances in Designs, Fabrication Methods, and Applications.Sensors (Basel, Switzerland) · 2025Review
- Democratizing advanced surgical guidance: decoupling the state-of-the-art from tertiary centers and breaking trail for autonomous robotic surgery in austere environments.Proceedings of SPIE--the International Society for Optical Engineering · 2025Article
- 4D Printing of Magnetically Responsive Materials and Their Applications.Research (Washington, D.C.) · 2025Review
- Recent Advances in 4D Printing: A Review of Current Smart Materials, Technologies, and Drug Delivery Systems.Current pharmaceutical design · 2025Review
- Unlocking Micro-Origami Energy Storage.ACS applied energy materials · 2024Review
- A microgripper based on electrothermal Al-SiOMicrosystems & nanoengineering · 2024Article
- Engineered Shape-Morphing Transitions in Hydrogels Through Suspension Bath Printing of Temperature-Responsive Granular Hydrogel Inks.Advanced materials (Deerfield Beach, Fla.) · 2024Article
- Design and Functionality of Trypsin-Triggered, Expandable Bovine Serum Albumin-Polyethylene Glycol Diacrylate Hydrogel Actuators.Small science · 2024Article
- Towards 4D printing in pharmaceutics.International journal of pharmaceutics: X · 2023Review
- Rapid and selective actuation of 3D-printed shape-memory composites via microwave heating.Scientific reports · 2023Article
- Diverse Applications of Three-Dimensional Printing in Biomedical Engineering: A Review.3D printing and additive manufacturing · 2023Review
- Phototriggered structures: Latest advances in biomedical applications.Acta pharmaceutica Sinica. B · 2023Review
- Utilizing 4D Printing to Design Smart Gastroretentive, Esophageal, and Intravesical Drug Delivery Systems.Advanced healthcare materials · 2023Review
2 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
We report on a therapeutic approach using thermo-responsive multi-fingered drug eluting devices. These therapeutic grippers referred to as theragrippers are shaped using photolithographic patterning and are composed of rigid poly(propylene fumarate) segments and stimuli-responsive poly(N-isopropylacrylamide-co-acrylic acid) hinges. They close above 32 °C allowing them to spontaneously grip onto tissue when introduced from a cold state into the body. Due to porosity in the grippers, theragrippers could also be loaded with fluorescent dyes and commercial drugs such as mesalamine and doxorubicin, which eluted from the grippers for up to seven days with first order release kinetics. In an in vitro model, theragrippers enhanced delivery of doxorubicin as compared to a control patch. We also released theragrippers into a live pig and visualized release of dye in the stomach. The design of such tissue gripping drug delivery devices offers an effective strategy for sustained release of drugs with immediate applicability in the gastrointestinal tract.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.