ArticleJournal of bacteriology2014
In vivo disassembly and reassembly of protein aggregates in Escherichia coli.
Article in Journal of bacteriology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 39 citations in OpenAlex.
- Curcumin-Based Nanoformulations for Oral Health: Mechanistic Insights, Antimicrobial Efficacy, and Future Clinical Perspectives.Biomedicines · 2026Review
- Deep learning on protein language model embeddings unlocks accurate prediction of protein solubility.Frontiers in microbiology · 2026Article
- Protein aggregates act as a deterministic disruptor during bacterial cell size homeostasis.Cellular and molecular life sciences : CMLS · 2023Article
- Impact of Protein Aggregates on Sporulation and Germination ofMicroorganisms · 2023Article
- Fundamental insights in early-stage inclusion body formation.Microbial biotechnology · 2023Article
- Update on the Protein Homeostasis Network inFrontiers in microbiology · 2022Review
- Synergetic Inactivation Mechanism of Protocatechuic Acid and High Hydrostatic Pressure againstFoods (Basel, Switzerland) · 2021Article
- Chromosome choreography during the non-binary cell cycle of a predatory bacterium.Current biology : CB · 2021Article
- Article
- Protein aggregation in bacteria.FEMS microbiology reviews · 2020Review
- Microbial ageing and longevity.Nature reviews. Microbiology · 2019Review
- Stress-induced protein aggregates shape population heterogeneity in bacteria.Current genetics · 2019Review
- Growth-driven displacement of protein aggregates along the cell length ensures partitioning to both daughter cells in Caulobacter crescentus.Molecular microbiology · 2019Article
- Perspectives of inclusion bodies for bio-based products: curse or blessing?Applied microbiology and biotechnology · 2019Review
- Protein aggregates encode epigenetic memory of stressful encounters in individual Escherichia coli cells.PLoS biology · 2018Article
- Interrelation between Tween and the membrane properties and high pressure tolerance of Lactobacillus plantarum.BMC microbiology · 2018Article
- Rapid phenotypic individualization of bacterial sister cells.Scientific reports · 2017Article
- Robustness of the Process of Nucleoid Exclusion of Protein Aggregates in Escherichia coli.Journal of bacteriology · 2016Article
- Severely Heat Injured Survivors ofFrontiers in microbiology · 2016Article
- Some Like It Hot: Heat Resistance ofFrontiers in microbiology · 2016Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Protein misfolding and aggregation are inevitable but detrimental cellular processes. Cells therefore possess protein quality control mechanisms based on chaperones and proteases that (re)fold or hydrolyze unfolded, misfolded, and aggregated proteins. Besides these conserved quality control mechanisms, the spatial organization of protein aggregates (PAs) inside the cell has been proposed as an important additional strategy to deal with their cytotoxicity. In the bacterium Escherichia coli, however, it remained unclear how this spatial organization is established and how this process of assembling PAs in the cell poles affects cellular physiology. In this report, high hydrostatic pressure was used to transiently reverse protein aggregation in living E. coli cells, allowing the subsequent (re)assembly of PAs to be studied in detail. This approach revealed PA assembly to be dependent on intracellular energy and metabolic activity, with the resulting PA structure being confined to the cell pole by nucleoid occlusion. Moreover, a correlation could be observed between the time needed for PA reassembly and the individual lag time of the cells, which might prevent symmetric segregation of cytotoxic PAs among siblings to occur and ensure rapid spatial clearance of molecular damage throughout the emerging population.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.