Evidence map›Paper›PMID 24633870›Full record

ArticleHaematologica2014

Clinically relevant doses of FLT3-kinase inhibitors quizartinib and midostaurin do not impair T-cell reactivity and function.

Denise Wolleschak, Thomas S Mack, Florian Perner, Stephanie Frey, Tina M Schnöder, Marie-Christine Wagner, Christine Höding, Marina C Pils, Andreas Parkner, Stefanie Kliche and 8 more

Abstract readLetter
In one paragraph

Article in Haematologica, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Denise WolleschakDepartment of Hematology and Oncology, Center of Internal Medicine, Otto-von-Guericke University Medical Center, Magdeburg, Germany.
Thomas S MackDepartment of Hematology and Oncology, Center of Internal Medicine, Otto-von-Guericke University Medical Center, Magdeburg, Germany.
Florian PernerDepartment of Hematology and Oncology, Center of Internal Medicine, Otto-von-Guericke University Medical Center, Magdeburg, Germany.
Stephanie FreyDepartment of Hematology and Oncology, Center of Internal Medicine, Otto-von-Guericke University Medical Center, Magdeburg, Germany.
Tina M SchnöderDepartment of Hematology and Oncology, Center of Internal Medicine, Otto-von-Guericke University Medical Center, Magdeburg, Germany.
Marie-Christine WagnerDepartment of Hematology and Oncology, Center of Internal Medicine, Otto-von-Guericke University Medical Center, Magdeburg, Germany.
Christine HödingDepartment of Hematology and Oncology, Center of Internal Medicine, Otto-von-Guericke University Medical Center, Magdeburg, Germany.
Marina C PilsMousepathology, Animal Experimental Unit, Helmholtz-Center for Infection Research, Braunschweig, Germany.
Andreas ParknerDepartment of Transfusion Medicine, Otto-von-Guericke University Medical Center, Magdeburg, Germany.
Stefanie KlicheInstitute of Molecular and Clinical Immunology, Otto-von-Guericke University Medical Center, Magdeburg, Germany.
Burkhart SchravenInstitute of Molecular and Clinical Immunology, Otto-von-Guericke University Medical Center, Magdeburg, Germany Department of Immune Control, Helmholtz Center for Infection Research, Braunschwei, Germany.
Katrin HebelDepartment of Experimental Pediatrics, Otto-von-Guericke University Medical Center, Magdeburg, Germany.
Monika Brunner-WeinzierlDepartment of Experimental Pediatrics, Otto-von-Guericke University Medical Center, Magdeburg, Germany.
Satish RanjanInstitute of Clinical Chemistry and Pathobiochemistry, Otto-von-Guericke University Medical Center, Magdeburg, Germany.
Berend IsermannInstitute of Clinical Chemistry and Pathobiochemistry, Otto-von-Guericke University Medical Center, Magdeburg, Germany.
Daniel B LipkaDepartment of Hematology and Oncology, Center of Internal Medicine, Otto-von-Guericke University Medical Center, Magdeburg, Germany German Cancer Research Center (DKFZ), Division of Epigenomics and Cancer Risk Factors, Heidelberg, Germany.
Thomas FischerDepartment of Hematology and Oncology, Center of Internal Medicine, Otto-von-Guericke University Medical Center, Magdeburg, Germany.
Florian H HeidelDepartment of Hematology and Oncology, Center of Internal Medicine, Otto-von-Guericke University Medical Center, Magdeburg, Germany florian.h.heidel@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Benzothiazolesfms-Like Tyrosine Kinase 3HumansPhenylurea CompoundsStaurosporineT-LymphocytesBenzothiazolesfms-Like Tyrosine Kinase 3midostaurinPhenylurea CompoundsquizartinibStaurosporineAC220FLT3-ITDPKC412T-cell activationtyrosine kinase inhibitors

Identifiers

PMID24633870
PMCPMC4040902

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.