Trial reportAIDS and behavior2014
Impact of an adherence intervention on the effectiveness of tenofovir gel in the CAPRISA 004 trial.
Trial report in AIDS and behavior, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05633056 (Adaptive Evaluation of mHealth and Conventional Adherence Support Interventions to Optimize Outcome With New Treatment Regimens for Drug-resistant Tuberculosis and HIV in South Africa), which is not on this map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Adaptive Evaluation of mHealth and Conventional Adherence Support Interventions to Optimize Outcome With New Treatment Regimens for Drug-resistant Tuberculosis and HIV in South Africa
Who cites it
19 citing papers in PubMed, 22 citations in OpenAlex.
- Impact and experience of participant engagement activities in supporting dapivirine ring use among participants enrolled in the phase III MTN-020/ASPIRE study.BMC public health · 2021Trial
- Integrated provision of topical pre-exposure prophylaxis in routine family planning services in South Africa: a non-inferiority randomized controlled trial.Journal of the International AIDS Society · 2019Trial
- Divergent adherence estimates with pharmacokinetic and behavioural measures in the MTN-003 (VOICE) study.Journal of the International AIDS Society · 2016Trial
- Trial
- Adherence in the CAPRISA 004 tenofovir gel microbicide trial.AIDS and behavior · 2014Trial
- Systematic Review of Use of Motivational Interviewing to Increase Pre-exposure Prophylaxis Care Continuum Participation.AIDS and behavior · 2026Article
- Evaluating Motivational Interviewing and Peer Adherence Support as Strategies to Improve Oral PrEP Adherence among HIV-Negative Adults in KwaZulu-Natal, South Africa.AIDS and behavior · 2026Article
- Article
- Prevention, Partners, and Power Imbalances: Women's Views on How Male Partners Affected Their Adherence to Vaginal Microbicide Gels During HIV Prevention Trials in Africa.Journal of acquired immune deficiency syndromes (1999) · 2020Article
- Article
- Motives for choosing, switching and stopping daily or event-driven pre-exposure prophylaxis - a qualitative analysis.Journal of the International AIDS Society · 2019Article
- Attitudes and perceptions towards novel objective measures of ARV-based vaginal ring use: Results from a global stakeholder survey.PloS one · 2017Article
- Blocking CXCL9 Decreases HIV-1 Replication and Enhances the Activity of Prophylactic Antiretrovirals in Human Cervical Tissues.Journal of acquired immune deficiency syndromes (1999) · 2016Article
- Perceptions and Experiences with the VOICE Adherence Strengthening Program (VASP) in the MTN-003 Trial.AIDS and behavior · 2015Article
- Motivational interviewing and specialty pharmacy.Journal of managed care & specialty pharmacy · 2015Article
- Article
- Pre-exposure prophylaxis for sexually-acquired HIV risk management: a review.HIV/AIDS (Auckland, N.Z.) · 2015Review
- Learning from the private sector: towards a keener understanding of the end-user for microbicide introduction planning.Journal of the International AIDS Society · 2014Article
- An interdisciplinary framework for measuring and supporting adherence in HIV prevention trials of ARV-based vaginal rings.Journal of the International AIDS Society · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 2 institutions in 1 country.
Funding
Abstract
High adherence is important in microbicide trials, but no adherence interventions to date have demonstrated empiric improvements in microbicide adherence or effectiveness. Approximately midway during the CAPRISA 004 trial, we implemented a novel adherence intervention (Adherence Support Program-ASP), based on an Information-Motivation-Behavioral Skills model and incorporating a Motivational Interviewing approach. We assessed the impact of the ASP on adherence and tenofovir gel effectiveness using a before-and-after comparison. Of the 889 women in the trial, 774 contributed 486.1 women-years of follow-up pre-ASP and 828 contributed 845.7 women-years of follow-up post-ASP. Median adherence rose from 53.6 % pre-ASP to 66.5 % post-ASP. Detectable tenofovir levels increased from 40.6 % pre-ASP to 62.5 % post-ASP in 64 women who had paired tenofovir drug samples. Gel effectiveness improved post-ASP; HIV incidence in the tenofovir gel arm was 24 % lower pre-ASP compared to 47 % lower post-ASP. Following implementation of the ASP, microbicide adherence improved with a concomitant increase in the effectiveness of tenofovir gel.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.