Trial reportClinical infectious diseases : an official publication of the Infectious Diseases Society of America2014
Hygiene strategies to prevent methicillin-resistant Staphylococcus aureus skin and soft tissue infections: a cluster-randomized controlled trial among high-risk military trainees.
Trial report in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01105767 (Evaluating Strategies to Prevent Methicillin-resistant Staphylococcus Aureus Skin and Soft Tissue Infections in Military Trainees), which is not on this map. Cited by 29 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Evaluating Strategies to Prevent Methicillin-resistant Staphylococcus Aureus Skin and Soft Tissue Infections in Military Trainees
Who cites it
29 citing papers in PubMed, 48 citations in OpenAlex.
- HOME2 Study: Household Versus Personalized Decolonization in Households of Children With Methicillin-Resistant Staphylococcus aureus Skin and Soft Tissue Infection-A Randomized Clinical Trial.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2021Trial
- Trial
- Reduction in Acute Respiratory Infection Among Military Trainees: Secondary Effects of a Hygiene-Based Cluster-Randomized Trial for Skin and Soft-Tissue Infection Prevention.Infection control and hospital epidemiology · 2016Trial
- Reduction in acute gastroenteritis among military trainees: secondary effects of a hygiene-based cluster-randomized trial for skin and soft tissue infection prevention.Infection control and hospital epidemiology · 2015Trial
- Correlation between nasal microbiome composition and remote purulent skin and soft tissue infections.Infection and immunity · 2015Trial
- Frequent use of chlorhexidine-based body wash associated with a reduction in methicillin-resistant Staphylococcus aureus nasal colonization among military trainees.Antimicrobial agents and chemotherapy · 2015Trial
- Prevalence of chlorhexidine-resistant methicillin-resistant Staphylococcus aureus following prolonged exposure.Antimicrobial agents and chemotherapy · 2014Trial
- Review
- Profiling of serum factors associated withFrontiers in immunology · 2023Article
- Management and Prevention of Staphylococcus aureus Infections in Children.Infectious disease clinics of North America · 2022Review
- Stopping Household Methicillin-resistant Staphylococcusaureus Transmission and Recurrent Infections: An Unmet Challenge.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2021Article
- Comparative Effectiveness Study of Home-Based Interventions to Prevent CA-MRSA Infection Recurrence.Antibiotics (Basel, Switzerland) · 2021Article
- Opportunities and Obstacles in the Prevention of Skin and Soft-Tissue Infections Among Military Personnel.Military medicine · 2019Article
- Impact of Decolonization Protocols and Recurrence in Pediatric MRSA Skin and Soft-Tissue Infections.The Journal of surgical research · 2019Article
- Prevention Strategies for Recurrent Community-Associated Staphylococcus aureus Skin and Soft Tissue Infections.Current infectious disease reports · 2019Review
- Antimicrobial approaches in the prevention of Staphylococcus aureus infections: a review.The Journal of antimicrobial chemotherapy · 2019Review
- Temporal shifts in the collective dermatologic microbiome of military trainees.Clinical, cosmetic and investigational dermatology · 2019Article
- Infection Control Practices and Methicillin-ResistantJournal of chiropractic medicine · 2018Article
- Decolonization ofJournal of healthcare engineering · 2018Review
- Conjugative Transfer of a Novel Staphylococcal Plasmid Encoding the Biocide Resistance Gene,Frontiers in microbiology · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 5 institutions in 1 country.
Funding
Abstract
backgroundEffective measures are needed to prevent methicillin-resistant Staphylococcus aureus (MRSA) skin and soft tissue infections (SSTIs) in high-risk community settings. The study objective was to evaluate the effect of personal hygiene-based strategies on rates of overall SSTI and MRSA SSTI.
methodsWe conducted a prospective, field-based, cluster-randomized trial in US Army Infantry trainees from May 2010 through January 2012. There were 3 study groups with incrementally increased education and hygiene-based interventions: standard (S), enhanced standard (ES), and chlorhexidine (CHG). The primary endpoints were incidence of overall SSTI and MRSA SSTI.
resultsThe study included 30 209 trainees constituting 540 platoons (168 S, 192 ES, and 180 CHG). A total of 1203 (4%) participants developed SSTI, 316 (26%) due to MRSA. The overall SSTI rate was 4.15 (95% confidence interval [CI], 3.77-4.58) per 100 person-cycles. SSTI rates by study group were 3.48 (95% CI, 2.87-4.22) for S, 4.18 (95% CI, 3.56-4.90) for ES, and 4.71 (95% CI, 4.03-5.50) for CHG. The MRSA SSTI rate per 100 person-cycles for all groups was 1.10 (95% CI, .91-1.32). MRSA SSTI rates by study group were 1.0 (95% CI, .70-1.42) for S, 1.29 (95% CI, .98-1.71) for ES, and 0.97 (95% CI, .70-1.36) for CHG.
conclusionsPersonal hygiene and education measures, including once-weekly use of chlorhexidine body wash, did not prevent overall SSTI or MRSA SSTI in a high-risk population of military trainees. CLINICAL TRIALS REGISTRATION: NCT01105767.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.