ArticleJournal of bone and mineral metabolism2015
Significant association among growing pains, vitamin D supplementation, and bone mineral status: results from a pilot cohort study.
Article in Journal of bone and mineral metabolism, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 37 citations in OpenAlex.
- Are Growing Pains Related to Vitamin D Deficiency? Efficacy of Vitamin D Therapy for Resolution of Symptoms.Medical principles and practice : international journal of the Kuwait University, Health Science Centre · 2015Trial
- Low vitamin D and folate levels are associated with costochondritis: a retrospective cross-sectional study on children with impaired bone health.BMC pediatrics · 2026Article
- Risk factors associated with growth pain disorder in children: a systematic review and meta-analysis.Frontiers in pediatrics · 2026Review
- Clinical Screening and Factors Influencing Growing Pain in Children with Recurrent Lower Limb Pain: A Controlled Study on Symptom Assessment and Motor Load.International journal of general medicine · 2026Article
- Article
- Article
- Growing pains in Danish preschool children: a descriptive study.Scientific reports · 2024Article
- Prevalence of growing pains in a general paediatric OPD: A descriptive, observational and cross-sectional study.Journal of family medicine and primary care · 2023Article
- Clinical, laboratory characteristics and growth outcomes of children with growing pains.Scientific reports · 2022Article
- Application of bone metabolic parameters in the diagnosis of growing pains.Journal of clinical laboratory analysis · 2022Article
- The effects of vitamin D supplementation in carpal tunnel syndrome treatment outcomes: a systematic review.Journal of experimental orthopaedics · 2021Review
- Vitamin D and Its Potential Interplay With Pain Signaling Pathways.Frontiers in immunology · 2020Review
- Growing pains: What do we know about etiology? A systematic review.World journal of orthopedics · 2019Article
- A pilot validation study of crowdsourcing systematic reviews: update of a searchable database of pediatric clinical trials of high-dose vitamin D.Translational pediatrics · 2017Article
- Perinatal Risk Factors and Genu Valgum Conducive to the Onset of Growing Pains in Early Childhood.Children (Basel, Switzerland) · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of our study was to analyze the possible relationship between growing pains, vitamin D levels, and bone mineral status. We enrolled 33 children affected by growing pains. Their pain intensity was evaluated through a questionnaire using the Wong-Baker Faces Pain Rating Scale for pain assessment. Serum 25-hydroxyvitamin D (25-OH-D), parathyroid hormone (PTH), and alkaline phosphatase levels were measured as well. A quantitative ultrasound assessment (QUS) was also done, measuring both the amplitude-dependent speed of sound (AD-SOS) and the bone transmission time (BTT), correlating, respectively, with bone density and with cortical thickness. After 3 and 24 months of vitamin D supplementation, we re-evaluated pain intensity and laboratory results. After 24 months we re-assessed QUS parameters. At the beginning of the study the children reported a mean growing pain intensity of 7.5 ± 1.6 SD. The mean values of 25-OH-D and PTH levels were 15.7 ± 6.9 ng/ml and 57.3 ± 27.3 pg/ml, respectively. The AD-SOS Z score was -0.53 ± 1.19 SD, and the mean value of the BTT Z score was -0.72 ± 0.96 SD. After the first 3 months of vitamin D supplementation we observed an increase in 25-OH-D levels (34.1 ± 17.8, p < 0.001) and a reduction in both PTH levels (47.3 ± 30.6, p = 0.135) and pain intensity (2.7 ± 2.2, p < 0.001). After 24 months we observed a further significant reduction in the pain intensity (3.9 ± 3.4, p < 0.001) and in PTH levels (43.7 ± 28.5, p = 0.004) and an improvement in the QUS parameters, in particular in BTT Z scores (p = 0.014). Our study suggests an interesting relationship between growing pains, vitamin D levels and bone mineral status.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.