ReviewPsychopharmacology2014
Drug abstinence: exploring animal models and behavioral treatment strategies.
Review in Psychopharmacology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 35 citations in OpenAlex.
- "Guide them to have a future orientation": qualitative findings in developing a reinforcement-based intervention to address alcohol use with American Indian emerging adults.Frontiers in public health · 2026Article
- The Stage-Based Model of Addiction-UsingInternational journal of molecular sciences · 2023Review
- Environmental enrichment facilitates electric barrier induced heroin abstinence after incubation of craving in male and female rats.Drug and alcohol dependence · 2023Article
- Acute nicotine treatment enhances compulsive-like remifentanil self-administration that persists despite contextual punishment.Addiction biology · 2022Article
- Does Traumatic Brain Injury Cause Risky Substance Use or Substance Use Disorder?Biological psychiatry · 2022Review
- Low-dose polypharmacology targeting dopamine D1 and D3 receptors reduces cue-induced relapse to heroin seeking in rats.Addiction biology · 2021Article
- Blockade of β-Adrenergic Receptors by Propranolol Disrupts Reconsolidation of Drug Memory and Attenuates Heroin Seeking.Frontiers in pharmacology · 2021Article
- Resurgence of punishment-suppressed cocaine seeking in rats.Experimental and clinical psychopharmacology · 2020Article
- Therapeutic efficacy of environmental enrichment for substance use disorders.Pharmacology, biochemistry, and behavior · 2020Review
- Beyond drug-induced alteration of glutamate homeostasis, astrocytes may contribute to dopamine-dependent intrastriatal functional shifts that underlie the development of drug addiction: A working hypothesis.The European journal of neuroscience · 2019Review
- Effects of adolescent caffeine consumption on cocaine self-administration and reinstatement of cocaine seeking.Journal of psychopharmacology (Oxford, England) · 2018Article
- Longer treatment with alternative non-drug reinforcement fails to reduce resurgence of cocaine or alcohol seeking in rats.Behavioural brain research · 2018Article
- N-acetylcysteine Facilitates Self-Imposed Abstinence After Escalation of Cocaine Intake.Biological psychiatry · 2016Article
- Higher rate alternative non-drug reinforcement produces faster suppression of cocaine seeking but more resurgence when removed.Behavioural brain research · 2016Article
- Effects of sex and remifentanil dose on rats' acquisition of responding for a remifentanil-conditioned reinforcer.Behavioural pharmacology · 2016Article
- The selective dopamine D3 receptor antagonist, SR 21502, reduces cue-induced reinstatement of heroin seeking and heroin conditioned place preference in rats.Drug and alcohol dependence · 2015Article
- Resurgence of sucrose and cocaine seeking in free-feeding rats.Behavioural brain research · 2015Article
- Sex Differences in the Reinstatement of Methamphetamine Seeking after Forced Abstinence in Sprague-Dawley Rats.Frontiers in psychiatry · 2015Article
- Effects of pramipexole on the acquisition of responding with opioid-conditioned reinforcement in the rat.Psychopharmacology · 2015Article
- Differences in extinction of cue-maintained conditioned responses associated with self-administration: alcohol versus a nonalcoholic reinforcer.Alcoholism, clinical and experimental research · 2014Article
Corrections and comments
- Commented on by
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and rationaleAn enormous amount of resources has been devoted to the development of pharmacotherapies for drug addiction, with relatively little or no long-term success reported. The current review argues that a successful drug addiction treatment program will likely be one that focuses on both the neural mechanisms and the environmental contingencies that mediate drug use. Further, because the neural mechanisms and environmental factors that support abstinence in humans are similar in laboratory animals, several animal models of abstinence and relapse have been developed. Thus, this review also compares the similarities in the mechanisms that lead to abstinence between animals and humans.
objectiveWe evaluate the construct and face validities of the behavioral strategies that help support human drug abstinence. Further, we crucially evaluate animal models by assessing their validity and utility in addressing human behavior that leads to long-term abstinence.
conclusionsWe found that the behavioral strategies with the greatest likelihood of supporting long-term abstinence are those that are carried out in drug addicts' natural setting(s) and while drug is readily available. Further, the behavioral strategies that may be most successful in supporting abstinence in humans are those that employ both positive consequences for abstinent related behavior and negative consequences for continued drug seeking or taking. Moreover, the animal models of abstinence and relapse that more closely represent the factors that support long-term abstinence in humans are those that limit their use of extinction or forced abstinence and present negative consequences for drug seeking and taking.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.