Evidence map›Paper›PMID 24633304›Full record

ArticleNature medicine2014

Tissue mechanics modulate microRNA-dependent PTEN expression to regulate malignant progression.

Janna K Mouw, Yoshihiro Yui, Laura Damiano, Russell O Bainer, Johnathon N Lakins, Irene Acerbi, Guanqing Ou, Amanda C Wijekoon, Kandice R Levental, Penney M Gilbert and 3 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 225 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
225citing papers in PubMed, 1 pooled it
18.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

225 citing papers in PubMed, 1 synthesis or guideline pooled it, 415 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Review
  4. Review
  5. Review
  6. Mechanical Cues Regulate Cargo Sorting and Export at the Golgi.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  7. Article
  8. Article
  9. Review
  10. Review
  11. Review
  12. Article
  13. Article
  14. Review
  15. Review
  16. Review
  17. Article
  18. Review
  19. Article
  20. Article

165 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 2 countries.

Janna K MouwCenter for Bioengineering and Tissue Regeneration, Department of Surgery, University of California San Francisco (UCSF), San Francisco, California, USA.
Yoshihiro YuiCenter for Bioengineering and Tissue Regeneration, Department of Surgery, University of California San Francisco (UCSF), San Francisco, California, USA.
Laura DamianoCenter for Bioengineering and Tissue Regeneration, Department of Surgery, University of California San Francisco (UCSF), San Francisco, California, USA.
Russell O BainerCenter for Bioengineering and Tissue Regeneration, Department of Surgery, University of California San Francisco (UCSF), San Francisco, California, USA.
Johnathon N LakinsCenter for Bioengineering and Tissue Regeneration, Department of Surgery, University of California San Francisco (UCSF), San Francisco, California, USA.
Irene AcerbiCenter for Bioengineering and Tissue Regeneration, Department of Surgery, University of California San Francisco (UCSF), San Francisco, California, USA.
Guanqing OuCenter for Bioengineering and Tissue Regeneration, Department of Surgery, University of California San Francisco (UCSF), San Francisco, California, USA.ORCID 0000000238881902
Amanda C WijekoonCenter for Bioengineering and Tissue Regeneration, Department of Surgery, University of California San Francisco (UCSF), San Francisco, California, USA.
Kandice R LeventalDepartment of Integrative Biology and Pharmacology, The University of Texas Health Science Center at Houston-Medical School, Houston, Texas, USA.
Penney M GilbertInstitute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Ontario, Canada.
E Shelley HwangDepartment of Surgery, Duke University Comprehensive Cancer Center, Durham, North Carolina, USA.
Yunn-Yi ChenDepartment of Pathology, UCSF, San Francisco, California, USA.
Valerie M Weaver1] Center for Bioengineering and Tissue Regeneration, Department of Surgery, University of California San Francisco (UCSF), San Francisco, California, USA. [2] Department of Anatomy and Department of Bioengineering and Therapeutic Sciences, UCSF, San Francisco, California, USA. [3] Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, UCSF, San Francisco, California, USA. [4] UCSF Helen Diller Comprehensive Cancer Center, UCSF, San Francisco, California, USA.
University of California, San Francisco · USDuke University · USThe University of Texas Health Science Center · USUniversity of Toronto · CA

Funding

TRANS-NETWORK PROJECTSU54CA143836 · NCI · UNIVERSITY OF CALIFORNIA BERKELEY · PI LIPHARDT, JAN T. · 2009 to 2014
$15.1M
TGF BETA SUPPRESSION AND PROMOTION OF MAMMARY CARCINOMASR01CA085492 · NCI · VANDERBILT UNIVERSITY · PI MOSES, HAROLD L, WEAVER, VALERIE MARIE · 2000 to 2015
$6.4M
Environmental Effect on the Mammary Gland across the LifespanU01ES019458 · NIEHS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI WERB, ZENA · 2010 to 2014
$2.5M
Collagen remodeling and tumor progressionR01CA138818 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI WEAVER, VALERIE MARIE · 2010 to 2014
$2.0M
NCI NIH HHS R01 CA085492NCI NIH HHS R01 CA138818NCI NIH HHS U54 CA143836NIEHS NIH HHS U01 ES019458
6 · The paper itself

Abstract

Tissue mechanics regulate development and homeostasis and are consistently modified in tumor progression. Nevertheless, the fundamental molecular mechanisms through which altered mechanics regulate tissue behavior and the clinical relevance of these changes remain unclear. We demonstrate that increased matrix stiffness modulates microRNA expression to drive tumor progression through integrin activation of β-catenin and MYC. Specifically, in human and mouse tissue, increased matrix stiffness induced miR-18a to reduce levels of the tumor suppressor phosphatase and tensin homolog (PTEN), both directly and indirectly by decreasing levels of homeobox A9 (HOXA9). Clinically, extracellular matrix stiffness correlated directly and significantly with miR-18a expression in human breast tumor biopsies. miR-18a expression was highest in basal-like breast cancers in which PTEN and HOXA9 levels were lowest, and high miR-18a expression predicted poor prognosis in patients with luminal breast cancers. Our findings identify a mechanically regulated microRNA circuit that can promote malignancy and suggest potential prognostic roles for HOXA9 and miR-18a levels in stratifying patients with luminal breast cancers.

Indexed as

ElasticityGene Expression Regulation, NeoplasticTumor MicroenvironmentAnimalsbeta CateninBreast NeoplasmsCell LineDisease ProgressionExtracellular MatrixFemaleHomeodomain ProteinsHumansMammary Glands, AnimalMammary Glands, HumanMiceMicroRNAsbeta Cateninhomeobox protein HOXA9Homeodomain ProteinsMicroRNAsMIRN18A microRNA, humanOncogene Protein p55(v-myc)PTEN Phosphohydrolase

Identifiers

PMID24633304
PMCPMC3981899
OpenAlexW2021597202

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.