ArticleNature genetics2014
Chalk5 encodes a vacuolar H(+)-translocating pyrophosphatase influencing grain chalkiness in rice.
Article in Nature genetics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 190 papers.
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Who cites it
190 citing papers in PubMed, 406 citations in OpenAlex.
- CRISPR/Cas-based genome editing for enhancing grain quality traits in rice (Plant signaling & behavior · 2026Review
- Improving Grain Shape of the Rice Variety Exiangsimiao by Introgressing the Long-Grain Allele ofInternational journal of molecular sciences · 2026Article
- Ghd7‑triggered transcriptional regulation for synergistically improving rice eating quality and yield.Nature communications · 2026Article
- A Multi-Gene Matrix for Precision Breeding of Rice Grain Quality.Plants (Basel, Switzerland) · 2026Article
- Negative Regulators of Rice Agronomic Traits: Functional Insights and Applications in Genome Editing-Based Breeding.Plant biotechnology journal · 2026Review
- Natural Variation and Expression of OsCFF1 Affect the Formation of Rice Chalkiness.Rice (New York, N.Y.) · 2026Article
- Decoding heat-induced chalkiness in rice: molecular mechanisms, genetic networks, and mitigation strategies for climate resilience.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2026Review
- OsABCB4 disruption impairs auxin homeostasis, delaying heading and compromising agronomic traits in rice.Journal of plant research · 2026Article
- OsMYB99 Modulates Grain Wax Biosynthesis and Redox Homeostasis to Control Head Rice Yield and Chalkiness.Plant biotechnology journal · 2026Article
- Determinants of Rice Grain Quality: Synergistic Roles of Genetics, Environment, and Agronomic Practices.International journal of molecular sciences · 2026Review
- D-amino acid aminotransferase1 regulates grain chalkiness in rice by modulating endoplasmic reticulum stress response.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Genetic Determinants and Breeding Strategies for Rice Cooking and Eating Quality: A Comprehensive Review.Plant biotechnology journal · 2026Review
- The OsMADS18-OsbZIP60 module plays a critical role in influencing grain chalkiness in rice.Science China. Life sciences · 2026Article
- Natural variation in OsTPS8 confers differential regulation of chalkiness and seed vigor in indica and japonica rice.Nature genetics · 2026Article
- Engineering non-coding DNA Elements in Rice: an Elegant Approach To fine-tune Agronomical Advantageous Traits.Rice (New York, N.Y.) · 2025Review
- A Natural Major Module Confers the Trade-Off between Phenotypic Mean and Plasticity of Grain Chalkiness in Rice.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Allelic value in gene regulation-implications for gene editing.Annals of botany · 2025Article
- Implementing marker covariates and multi-trait genomic selection models to improve grain milling, appearance, cooking, and edible quality in rice (Oryza sativa L.).The plant genome · 2025Article
- Functional Analysis of the Autophagy-Related GenePlants (Basel, Switzerland) · 2025Article
- OsBZR4 regulates temperature-dependent embryogenesis in rice.Nature communications · 2025Article
130 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
13 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Grain chalkiness is a highly undesirable quality trait in the marketing and consumption of rice grain. However, the molecular basis of this trait is poorly understood. Here we show that a major quantitative trait locus (QTL), Chalk5, influences grain chalkiness, which also affects head rice yield and many other quality traits. Chalk5 encodes a vacuolar H(+)-translocating pyrophosphatase (V-PPase) with inorganic pyrophosphate (PPi) hydrolysis and H(+)-translocation activity. Elevated expression of Chalk5 increases the chalkiness of the endosperm, putatively by disturbing the pH homeostasis of the endomembrane trafficking system in developing seeds, which affects the biogenesis of protein bodies and is coupled with a great increase in small vesicle-like structures, thus forming air spaces among endosperm storage substances and resulting in chalky grain. Our results indicate that two consensus nucleotide polymorphisms in the Chalk5 promoter in rice varieties might partly account for the differences in Chalk5 mRNA levels that contribute to natural variation in grain chalkiness.
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