ArticlePloS one2014
Early detection of widespread progressive brain injury after cardiac arrest: a single case DTI and post-mortem histology study.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 14 citations in OpenAlex.
- Correlation of blood biomarkers with microstructural brain injury in survivors of out-of-hospital cardiac arrest.Brain communications · 2026Article
- The independent prognostic value of brain diffusion tensor imaging in comatose patients after cardiac arrest.Brain informatics · 2025Article
- Limbic pathway vulnerability associates with neurologic outcome in children after cardiac arrest.Resuscitation · 2023Article
- Extensive Delayed Brain Atrophy after Resuscitation in a Patient with Multiple System Atrophy.Frontiers in neurology · 2017Article
- A case of traumatic cardiopulmonary arrest with good neurological outcome predicted by amplitude-integrated electroencephalogram.International journal of surgery case reports · 2017Article
- High-field magnetic resonance imaging of the human temporal lobe.NeuroImage. Clinical · 2015Article
- Diffusion tensor imaging and white matter abnormalities in patients with disorders of consciousness.Frontiers in human neuroscience · 2014Review
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveWe tested the hypothesis in sense of a proof of principle that white matter (WM) degeneration after cardiopulmonary arrest (CPA) can be assessed much earlier by diffusion tensor imaging (DTI) than by conventional MRI.
methodsWe performed DTI and T2-weighted FLAIR imaging over four serial acquisitions of a 76-year-old man with unresponsive wakefulness syndrome at day 41, 75, 173 and 284 after CPA. DTI was also performed in ten healthy control subjects. Fractional anisotropy (FA) derived from DTI was assessed in eleven regions of interest within the cerebral white matter (WM) and compared with post-mortem neuropathological findings.
resultsIn contrast to conventional FLAIR images that revealed only circumscribed WM damage, the first DTI demonstrated significant reduction of FA across the whole WM. The following FLAIR images (MRI 2-4) revealed increasing atrophy and leukoaraiosis paralleled by clinical deterioration with reduction of wakefulness and intractable seizures. Neuropathological findings confirmed the widespread and marked brain injury following CPA.
conclusionDTI may help to evaluate microstructural brain damage following CPA and may have predictive value for further evolution of cerebral degeneration in the chronic phase after CPA.
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