ArticleInflammation research : official journal of the European Histamine Research Society ... [et al.]2014
Sulfated polysaccharides isolated from the green seaweed Caulerpa racemosa plays antinociceptive and anti-inflammatory activities in a way dependent on HO-1 pathway activation.
Article in Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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18 citing papers in PubMed, 74 citations in OpenAlex.
- Bioproducts from marine macroalgae Caulerpa taxifolia: production of biodiesel, biochar and biopolysaccharide using biorefinery approach.World journal of microbiology & biotechnology · 2026Article
- Therapeutic potential of seaweeds and their biofabricated nanoparticles in treating urolithiasis: A review.Heliyon · 2025Review
- Marine Microorganism Molecules as Potential Anti-Inflammatory Therapeutics.Marine drugs · 2024Review
- Review
- Sulfated polysaccharides fromHeliyon · 2024Article
- Therapeutic Potential and Nutraceutical Profiling of North Bornean Seaweeds: A Review.Marine drugs · 2022Review
- Antidiabetic and Nephroprotective Effects of Polysaccharide Extract from the SeaweedDiabetes, metabolic syndrome and obesity : targets and therapy · 2021Article
- Invasive Seaweeds in the Iberian Peninsula: A Contribution for Food Supply.Marine drugs · 2020Review
- Bioinformatic Characterization of Sulfotransferase Provides New Insights for the Exploitation of Sulfated Polysaccharides inInternational journal of molecular sciences · 2020Article
- Effect of orally administered combination ofResearch in pharmaceutical sciences · 2020Article
- Immunostimulatory Effect of Sulfated Galactans from the Green SeaweedMarine drugs · 2020Article
- Marine Alkaloids with Anti-Inflammatory Activity: Current Knowledge and Future Perspectives.Marine drugs · 2020Review
- Orofacial antinociceptive effect of sulphated polysaccharide from the marine algae Hypnea pseudomusciformis in rodents.Inflammopharmacology · 2019Article
- Transcriptional response of cultured porcine intestinal epithelial cells to micro algae extracts in the presence and absence of enterotoxigenicGenes & nutrition · 2019Article
- Fishing for Targets of Alien Metabolites: A Novel Peroxisome Proliferator-Activated Receptor (PPAR) Agonist from a Marine Pest.Marine drugs · 2018Article
- Gastroprotective Effects of Sulphated Polysaccharides from the Alga Caulerpa mexicana Reducing Ethanol-Induced Gastric Damage.Pharmaceuticals (Basel, Switzerland) · 2018Article
- Observing Anti-inflammatory and Anti-nociceptive Activities of Glycyrrhizin Through Regulating COX-2 and Pro-inflammatory Cytokines Expressions in Mice.Inflammation · 2015Article
- Mechanisms involved in the anti-inflammatory action of a polysulfated fraction from Gracilaria cornea in rats.PloS one · 2015Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveMarine algae are abundant sources of sulfated polysaccharides with various biological activities. Consequently, their biomolecules are of great of commercial interest. In this study, we investigated the potential antinociceptive activity of a sulfated polysaccharide obtained from the green seaweed Caulerpa racemosa (CrII) and the involvement of the hemoxigenase-1 (HO-1) pathway in its anti-inflammatory effect.
methodsWe used a systemic evaluation to verify possible toxic effects of Crll after consecutive treatments. Swiss mice and Wistar rats were used for all experiments.
resultsIn Swiss mice, CrII (0.01, 0.1 and 1.0 mg/kg) significantly reduced the number of abdominal contortions and the duration of paw licking in the second phase after treatment with acetic acid and formalin, respectively. However, CrII was unable to prolong the reaction time of thermally stimulated animals. The anti-inflammatory effect of CrII (0.01, 0.1 and 1.0 mg/kg) was evidenced by a decreased number of leukocytes in the peritoneal cavities of the rats. CrII (0.01, 0.1 and 1.0 mg/kg) also reduced the amount of paw edema induced by carrageenan (Cg) and dextran. The anti-inflammatory effect of CrII was confirmed by reduced levels of myeloperoxidase in the paw tissue of the Cg groups. After inhibition with ZnPP IX, a specific HO-1 phenotype inhibitor, the anti-inflammatory effect of CrII was no longer observed in Cg-induced paw edema tests. Consecutive Crll (1.0 mg/kg) for 14 days did not change any biochemical or histopathological parameters, or cause mortality of mice.
conclusionsCrII did not produce any signs of toxicity and effectively decreased nociception and inflammation. Also, the anti-inflammatory effect of Crll is at least in part dependent on the integrity of the HO-1 pathway.
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