ArticleLab on a chip2014
Defined topologically-complex protein matrices to manipulate cell shape via three-dimensional fiber-like patterns.
Article in Lab on a chip, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed, 24 citations in OpenAlex.
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- Revisiting tissue tensegrity: Biomaterial-based approaches to measure forces across length scales.APL bioengineering · 2021Review
- Mechanobiological regulation of placental trophoblast fusion and function through extracellular matrix rigidity.Scientific reports · 2020Article
- Quick liquid packaging: Encasing water silhouettes by three-dimensional polymer membranes.Science advances · 2019Article
- Large-scale patterning of single cells and cell clusters in hydrogels.Scientific reports · 2018Article
- For whom the cells pull: Hydrogel and micropost devices for measuring traction forces.Methods (San Diego, Calif.) · 2016Review
- The Collapse and Expansion of Liquid-Filled Elastic Channels and Cracks.Journal of applied mechanics · 2015Article
- Multiscale assembly for tissue engineering and regenerative medicine.Trends in biotechnology · 2015Review
- Electrospun Scaffolds for Osteoblast Cells: Peptide-Induced Concentration-Dependent Improvements of Polycaprolactone.PloS one · 2015Article
- Fracture-based fabrication of normally closed, adjustable, and fully reversible microscale fluidic channels.Small (Weinheim an der Bergstrasse, Germany) · 2014Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
Culturing cells in three-dimensional (3D) environments has been shown to significantly influence cell function, and may provide a more physiologically relevant environment within which to study the behavior of specific cell types. 3D tissues typically present a topologically complex fibrous adhesive environment, which is technically challenging to replicate in a controlled manner. Micropatterning technologies have provided significant insights into cell-biomaterial interactions, and can be used to create fiber-like adhesive structures, but are typically limited to flat culture systems; the methods are difficult to apply to topologically-complex surfaces. In this work, we utilize crack formation in multilayered microfabricated materials under applied strain to rapidly generate well-controlled and topologically complex 'fiber-like' adhesive protein patterns, capable of supporting cell culture and controlling cell shape on three-dimensional patterns. We first demonstrate that the features of the generated adhesive environments such as width, spacing and topology can be controlled, and that these factors influence cell morphology. The patterning technique is then applied to examine the influence of fiber structure on the nuclear morphology and actin cytoskeletal structure of cells cultured in a nanofibrous biomaterial matrix.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.