ArticlePsychosomatic medicine2014
Childhood adversity and inflammation in breast cancer survivors.
Article in Psychosomatic medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
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Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.
- The Association Between Adverse Childhood Experiences and Risk of Cancer in Adulthood: A Systematic Review of the Literature.Pediatrics · 2016Pooled it
- Emerging Perspectives on Adverse Childhood Experiences and Brain Cancer Immunotherapy.Cancers · 2026Article
- Associations Between Childhood Adversity and Pain in Breast Cancer Survivors.Biopsychosocial science and medicine · 2026Article
- Associations between adverse childhood experiences and physical activity domains among middle-aged and older adults: a national analysis.BMC public health · 2026Article
- Casting a long shadow: Exploring the link between childhood maltreatment and cancer in adulthood.PloS one · 2026Article
- Psychosocial stressors and breast cancer gene expression in the Black Women's Health Study.Breast cancer research and treatment · 2024Article
- Suicide and Inflammation.Advances in experimental medicine and biology · 2023Article
- A Comprehensive Review on Multifaceted Mechanisms Involved in the Development of Breast Cancer Following Adverse Childhood Experiences (ACEs).International journal of environmental research and public health · 2022Review
- Racial Disparity in Quadruple Negative Breast Cancer: Aggressive Biology and Potential Therapeutic Targeting and Prevention.Cancers · 2022Review
- Cancer-related accelerated ageing and biobehavioural modifiers: a framework for research and clinical care.Nature reviews. Clinical oncology · 2022Review
- A Cross-Sectional Exploration of Cytokine-Symptom Networks in Breast Cancer Survivors Using Network Analysis.The Canadian journal of nursing research = Revue canadienne de recherche en sciences infirmieres · 2021Article
- Immune and Epigenetic Pathways Linking Childhood Adversity and Health Across the Lifespan.Frontiers in psychology · 2021Review
- Immuno-inflammatory changes across phases of early psychosis: The impact of antipsychotic medication and stage of illness.Schizophrenia research · 2020Article
- Early childhood adversity in adult patients with metastatic lung cancer: Cross-sectional analysis of symptom burden and inflammation.Brain, behavior, and immunity · 2020Article
- Childhood maltreatment and monocyte gene expression among women with breast cancer.Brain, behavior, and immunity · 2020Article
- Trust as a mediator in the relationship between childhood sexual abuse and IL-6 level in adulthood.PloS one · 2020Article
- Exploring Relationships Among Peripheral Amyloid Beta, Tau, Cytokines, Cognitive Function, and Psychosomatic Symptoms in Breast Cancer Survivors.Biological research for nursing · 2020Article
- Associations between adverse childhood family environments and blood pressure differ between men and women.PloS one · 2019Article
- Social factors matter in cancer risk and survivorship.Cancer causes & control : CCC · 2018Article
- Features of Immunosenescence in Women Newly Diagnosed With Breast Cancer.Frontiers in immunology · 2018Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
objectiveElevated inflammation predicts behavioral symptoms, disease progression, and mortality in patients with breast cancer and breast cancer survivors, although predictors of inflammation remain largely unknown. Adverse experiences in childhood have been associated with higher rates of psychological and physical illness, and elevated inflammatory activity in studies of healthy adults. However, little research has examined the association between childhood adversity and inflammation in the context of cancer, where inflammation is particularly relevant for health.
methodsThe current study examined the association between three types of childhood adversity--abuse, neglect, and a chaotic home environment--and inflammatory markers (interleukin [IL]-6 and C-reactive protein), in breast cancer survivors who had completed primary cancer treatment 1 year earlier (n = 152).
resultsThe combined measure of childhood adversity was associated with elevations in plasma levels of IL-6 (B = 0.009, p = .027, η2 = 0.027, after controlling for age, body mass index, ethnicity, alcohol use, and cancer treatment (surgery, radiation, and/or chemotherapy). Examination of individual types of adversity demonstrated a positive association between abuse and IL-6 (B = 0.043, p = .030, η = 0.026), chaotic home environment and IL-6 (B = 0.031, p = .005, η = 0.043), and chaotic home environment and soluble tumor necrosis factor receptor type II (B = 0.012, p = .009, η2 = 0.037), after controlling for relevant confounds.
conclusionChildhood adversity was associated with elevated markers of inflammation in breast cancer survivors, with potential negative implications for health and well-being. In particular, chaotic home environment showed unique links with inflammatory outcomes.
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Registered trials
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