Evidence map›Paper›PMID 24632681›Full record

ArticlePediatric research2014

Intrauterine Candida albicans infection elicits severe inflammation in fetal sheep.

Matthew S Payne, Matthew W Kemp, Suhas G Kallapur, Paranthaman Senthamarai Kannan, Masatoshi Saito, Yuichiro Miura, John P Newnham, Sarah Stock, Demelza J Ireland, Boris W Kramer and 1 more

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In one paragraph

Article in Pediatric research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
3.4field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.

  1. Pooled it
  2. Treatment ofAJOG global reports · 2026
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  5. The diagnostic performance of the beta-glucan assay in the detection of intra-amniotic infection with Candida species.The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians · 2019
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 2 countries.

Matthew S PayneSchool of Women's and Infants' Health, The University of Western Australia, Perth, Australia.
Matthew W KempSchool of Women's and Infants' Health, The University of Western Australia, Perth, Australia.
Suhas G Kallapur1] School of Women's and Infants' Health, The University of Western Australia, Perth, Australia [2] Division of Pulmonary Biology, Cincinnati Children's Hospital Medical Center, University of Cincinnati School of Medicine, Cincinnati, Ohio.
Paranthaman Senthamarai KannanDivision of Pulmonary Biology, Cincinnati Children's Hospital Medical Center, University of Cincinnati School of Medicine, Cincinnati, Ohio.
Masatoshi Saito1] School of Women's and Infants' Health, The University of Western Australia, Perth, Australia [2] Division of Perinatal Medicine, Tohoku University Hospital, Sendai, Japan.
Yuichiro Miura1] School of Women's and Infants' Health, The University of Western Australia, Perth, Australia [2] Division of Perinatal Medicine, Tohoku University Hospital, Sendai, Japan.
John P NewnhamSchool of Women's and Infants' Health, The University of Western Australia, Perth, Australia.
Sarah Stock1] School of Women's and Infants' Health, The University of Western Australia, Perth, Australia [2] MRC Centre for Reproductive Health, Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK.
Demelza J IrelandSchool of Women's and Infants' Health, The University of Western Australia, Perth, Australia.
Boris W Kramer1] School of Women's and Infants' Health, The University of Western Australia, Perth, Australia [2] Department of Paediatrics, School of Oncology and Developmental Biology, Maastricht University Medical Center, Maastricht, The Netherlands.
Alan H Jobe1] School of Women's and Infants' Health, The University of Western Australia, Perth, Australia [2] Division of Pulmonary Biology, Cincinnati Children's Hospital Medical Center, University of Cincinnati School of Medicine, Cincinnati, Ohio.
University of Western Australia · AUCincinnati Children's Hospital Medical Center · US

Funding

Mechanisms of Fetal Inflammatory Response Syndrome Induced by ChorioamnionitisR01HD057869 · NICHD · CINCINNATI CHILDRENS HOSP MED CTR · PI KALLAPUR, SUHAS · 2009 to 2013
$1.6M
Medical Research Council G1002033NICHD NIH HHS HD57869NICHD NIH HHS R01 HD057869
6 · The paper itself

Abstract

backgroundPreventing preterm birth and subsequent adverse neonatal sequelae is among the greatest clinical challenges of our time. Recent studies suggest a role for Candida spp. in preterm birth and fetal injury, as a result of their colonization of either the vagina and/or the amniotic cavity. We hypothesized that intraamniotic Candida albicans would cause a vigorous, acute fetal inflammatory response.

methodsSheep carrying singleton pregnancies received single intraamniotic injections of either saline (control) or 10(7) colony-forming units C. albicans 1 or 2 d prior to surgical delivery and euthanasia at 124 ± 2 d gestation.

resultsColonization of the amniotic cavity by C. albicans resulted in a modest inflammatory response at 1 d and florid inflammation at 2 d, characterized by fetal thrombocytopenia, lymphopenia, and significant increases of inflammatory cytokines/chemokines in the fetal membranes skin, lung, and the amniotic fluid.

conclusionAcute colonization of the amniotic cavity by C. albicans causes severe intrauterine inflammation and fetal injury. C. albicans is a potent fetal pathogen that can contribute to adverse pregnancy outcomes.

Indexed as

Candida albicansAnalysis of VarianceAnimalsCandidiasisCytokinesEnzyme-Linked Immunosorbent AssayFemaleFetusHydrocortisoneInflammationLungPregnancyRNA, MessengerSheepSheep DiseasesSkinCytokinesHydrocortisoneRNA, Messenger

Identifiers

PMID24632681
PMCPMC4530618
OpenAlexW2115802345

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.